Rescue of arrested RNA polymerase II complexes
Research output: Contribution to journal › Review › Research › peer-review
In the past few months, several discoveries relating to the mechanism underlying transcription-coupled DNA repair (TCR) have been reported. These results make it timely to propose a hypothesis for how eukaryotic cells might deal with arrested RNA polymerase II (Pol II) complexes. In this model, the transcription-repair coupling factor Cockayne Syndrome B (or the yeast equivalent Rad26) uses DNA translocase activity to remodel the Pol II-DNA interface, possibly to push the polymerase past the obstruction or to remove it from the DNA so that repair can take place if the obstacle is a DNA lesion. However, when this action is not possible and Pol II is left irreversibly trapped on DNA, the polymerase is instead ubiquitylated and eventually removed by proteolysis.
Original language | English |
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Journal | Journal of Cell Science |
Volume | 116 |
Issue number | 3 |
Pages (from-to) | 447-451 |
Number of pages | 5 |
ISSN | 0021-9533 |
DOIs | |
Publication status | Published - 1 Feb 2003 |
Externally published | Yes |
- Cockayne syndrome, Def1, RNA polymerase II, Swi/Snf, Transcript elongation, Transcription-coupled repair, Ubiquitylation
Research areas
ID: 331041682