Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders
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Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders. / Torstensen, Eva Wiberg; Haubjerg Østerby, Niels Christian; Kornum, Birgitte Rahbek; Wanscher, Benedikte; Mignot, Emmanuel; Barløse, Mads; Jennum, Poul Jørgen.
In: Sleep Medicine, Vol. 110, 2023, p. 91-98.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders
AU - Torstensen, Eva Wiberg
AU - Haubjerg Østerby, Niels Christian
AU - Kornum, Birgitte Rahbek
AU - Wanscher, Benedikte
AU - Mignot, Emmanuel
AU - Barløse, Mads
AU - Jennum, Poul Jørgen
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Background: The diagnosis of narcolepsy is based on clinical information, combined with polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT). PSG and the MSLT are moderately reliable at diagnosing narcolepsy type 1 (NT1) but unreliable for diagnosing narcolepsy type 2 (NT2). This is a problem, especially given the increased risk of a false-positive MSLT in the context of circadian misalignment or sleep deprivation, both of which commonly occur in the general population. Aim: We aimed to clarify the accuracy of PSG/MSLT testing in diagnosing NT1 versus controls without sleep disorders. Repeatability and reliability of PSG/MSLT testing and temporal changes in clinical findings of patients with NT1 versus patients with hypersomnolence with normal hypocretin-1 were compared. Method: 84 patients with NT1 and 100 patients with non-NT1-hypersomnolence disorders, all with congruent cerebrospinal fluid hypocretin-1 (CSF-hcrt-1) levels, were included. Twenty-five of the 84 NT1 patients and all the hypersomnolence disorder patients underwent a follow-up evaluation consisting of clinical assessment, PSG, and a modified MSLT. An additional 68 controls with no sleep disorders were assessed at baseline. Conclusion: Confirming results from previous studies, we found that PSG and our modified MSLT accurately and reliably diagnosed hypocretin-deficient NT1 (accuracy = 0.88, reliability = 0.80). Patients with NT1 had stable clinical and electrophysiological presentations over time that suggested a stable phenotype. In contrast, the PSG/MSLT results of patients with hypersomnolence, and normal CSF-hcrt-1 had poor reliability (0.32) and low repeatability.
AB - Background: The diagnosis of narcolepsy is based on clinical information, combined with polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT). PSG and the MSLT are moderately reliable at diagnosing narcolepsy type 1 (NT1) but unreliable for diagnosing narcolepsy type 2 (NT2). This is a problem, especially given the increased risk of a false-positive MSLT in the context of circadian misalignment or sleep deprivation, both of which commonly occur in the general population. Aim: We aimed to clarify the accuracy of PSG/MSLT testing in diagnosing NT1 versus controls without sleep disorders. Repeatability and reliability of PSG/MSLT testing and temporal changes in clinical findings of patients with NT1 versus patients with hypersomnolence with normal hypocretin-1 were compared. Method: 84 patients with NT1 and 100 patients with non-NT1-hypersomnolence disorders, all with congruent cerebrospinal fluid hypocretin-1 (CSF-hcrt-1) levels, were included. Twenty-five of the 84 NT1 patients and all the hypersomnolence disorder patients underwent a follow-up evaluation consisting of clinical assessment, PSG, and a modified MSLT. An additional 68 controls with no sleep disorders were assessed at baseline. Conclusion: Confirming results from previous studies, we found that PSG and our modified MSLT accurately and reliably diagnosed hypocretin-deficient NT1 (accuracy = 0.88, reliability = 0.80). Patients with NT1 had stable clinical and electrophysiological presentations over time that suggested a stable phenotype. In contrast, the PSG/MSLT results of patients with hypersomnolence, and normal CSF-hcrt-1 had poor reliability (0.32) and low repeatability.
KW - Diagnostic validity
KW - Electrophysiology
KW - Hypocretin-1
KW - Narcolepsy
KW - Reliability
U2 - 10.1016/j.sleep.2023.07.029
DO - 10.1016/j.sleep.2023.07.029
M3 - Journal article
C2 - 37544279
AN - SCOPUS:85166665646
VL - 110
SP - 91
EP - 98
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -
ID: 362738260