Repeated exposure to hair dye induces regulatory T cells in mice
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Repeated exposure to hair dye induces regulatory T cells in mice. / Rubin, I M C; Dabelsteen, S; Nielsen, M M; White, I R; Johansen, J D; Geisler, Carsten; Bonefeld, C M.
In: British Journal of Dermatology, Vol. 163, No. 5, 2010, p. 992-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Repeated exposure to hair dye induces regulatory T cells in mice
AU - Rubin, I M C
AU - Dabelsteen, S
AU - Nielsen, M M
AU - White, I R
AU - Johansen, J D
AU - Geisler, Carsten
AU - Bonefeld, C M
N1 - © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
PY - 2010
Y1 - 2010
N2 - We have recently shown that commercial p-phenylenediamine (PPD)-containing hair dyes are potent immune activators that lead to severe contact hypersensitivity in an animal model. However, only a minority of people exposed to permanent hair dyes develops symptomatic contact hypersensitivity. This suggests that the majority of people exposed to hair dyes does not become sensitized or develop immunological tolerance.
AB - We have recently shown that commercial p-phenylenediamine (PPD)-containing hair dyes are potent immune activators that lead to severe contact hypersensitivity in an animal model. However, only a minority of people exposed to permanent hair dyes develops symptomatic contact hypersensitivity. This suggests that the majority of people exposed to hair dyes does not become sensitized or develop immunological tolerance.
KW - Animals
KW - Cell Proliferation
KW - Dermatitis, Allergic Contact
KW - Disease Models, Animal
KW - Ear, External
KW - Flow Cytometry
KW - Hair Dyes
KW - Immunohistochemistry
KW - Inflammation
KW - Interferon-gamma
KW - Mice
KW - Mice, Inbred BALB C
KW - T-Lymphocytes, Regulatory
U2 - 10.1111/j.1365-2133.2010.09988.x
DO - 10.1111/j.1365-2133.2010.09988.x
M3 - Journal article
C2 - 20716223
VL - 163
SP - 992
EP - 998
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 5
ER -
ID: 33732598