Regulation of blood flow by prostaglandins
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Regulation of blood flow by prostaglandins. / Boushel, Robert Christopher; Langberg, H; Risum, N; Kjaer, M.
In: Current Vascular Pharmacology, Vol. 2, No. 2, 01.04.2004, p. 191-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Regulation of blood flow by prostaglandins
AU - Boushel, Robert Christopher
AU - Langberg, H
AU - Risum, N
AU - Kjaer, M
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Prostaglandins (PGs) belong to the family of prostanoids together with thromboxanes and are produced mainly from arachadonic acid by the enzyme cyclooxygenase. PGs are known to stimulate platelet aggregation, mediate inflammation and edema, play a role in bone metabolism and in biological adaptation of connective tissues e.g. tendon. This review covers the role of PG for mediating tissue blood flow at rest and during increases in metabolic demand such as exercise and reactive hyperaemia. There is strong evidence that PGs contribute to elevate blood flow at rest and during reactive hyperaemia in a variety of tissues. Their role for regulating the large increases in muscle blood flow during exercise is less clear which may be explained by redundant mechanisms. Several interactions are known to exist between specific vasodilator substances, and therefore PGs can act in synergy with other substances and contribute to functional hyperaemia. Furthermore, there is evidence for differential, tissue-specific influences of PGs where their influence on blood flow during exercise may be profound.
AB - Prostaglandins (PGs) belong to the family of prostanoids together with thromboxanes and are produced mainly from arachadonic acid by the enzyme cyclooxygenase. PGs are known to stimulate platelet aggregation, mediate inflammation and edema, play a role in bone metabolism and in biological adaptation of connective tissues e.g. tendon. This review covers the role of PG for mediating tissue blood flow at rest and during increases in metabolic demand such as exercise and reactive hyperaemia. There is strong evidence that PGs contribute to elevate blood flow at rest and during reactive hyperaemia in a variety of tissues. Their role for regulating the large increases in muscle blood flow during exercise is less clear which may be explained by redundant mechanisms. Several interactions are known to exist between specific vasodilator substances, and therefore PGs can act in synergy with other substances and contribute to functional hyperaemia. Furthermore, there is evidence for differential, tissue-specific influences of PGs where their influence on blood flow during exercise may be profound.
KW - Animals
KW - Blood Circulation
KW - Clinical Trials as Topic
KW - Exercise
KW - Humans
KW - Hyperemia
KW - Muscle, Skeletal
KW - Prostaglandins
KW - Regional Blood Flow
KW - Rest
KW - Vasodilation
KW - Vasodilator Agents
M3 - Journal article
C2 - 15320520
VL - 2
SP - 191
EP - 197
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
SN - 1570-1611
IS - 2
ER -
ID: 33816660