Regulation and limitations to fatty acid oxidation during exercise
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Regulation and limitations to fatty acid oxidation during exercise. / Jeppesen, Jacob; Kiens, Bente.
In: Journal of Physiology, Vol. 590, No. 5, 2012, p. 1059-1068.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Regulation and limitations to fatty acid oxidation during exercise
AU - Jeppesen, Jacob
AU - Kiens, Bente
N1 - CURIS 2012 5200 025
PY - 2012
Y1 - 2012
N2 - Fatty acids (FA) as fuel for energy utilization during exercise originate from different sources: FA transported in the circulation either bound to albumin or as triacylglycerol (TG) carried by very low density lipoproteins (VLDL) and FA from lipolysis of muscle TG stores (IMTG). Despite a high rate of energy expenditure during high intensity exercise the total fatty acid oxidation is suppressed to below that observed during moderate intensity exercise. Although this has been known for many years, the mechanisms behind this phenomenon are still not fully elucidated. A failure of adipose tissue to deliver sufficient fatty acids to exercising muscle has been proposed, but evidence is emerging that factors within the muscle might be of more importance. The high rate of glycolysis during high intensity exercise might be the "driving force" via the increased production of acetyl CoA which in turn is trapped by carnitine. This will lead to less availability of free carnitine for fatty acid transport into mitochondria. This review summarizes our present view on how FA metabolism is regulated during exercise with a special focus on the limitations in FA oxidation in the transition from moderate to high intensity exercise in humans.
AB - Fatty acids (FA) as fuel for energy utilization during exercise originate from different sources: FA transported in the circulation either bound to albumin or as triacylglycerol (TG) carried by very low density lipoproteins (VLDL) and FA from lipolysis of muscle TG stores (IMTG). Despite a high rate of energy expenditure during high intensity exercise the total fatty acid oxidation is suppressed to below that observed during moderate intensity exercise. Although this has been known for many years, the mechanisms behind this phenomenon are still not fully elucidated. A failure of adipose tissue to deliver sufficient fatty acids to exercising muscle has been proposed, but evidence is emerging that factors within the muscle might be of more importance. The high rate of glycolysis during high intensity exercise might be the "driving force" via the increased production of acetyl CoA which in turn is trapped by carnitine. This will lead to less availability of free carnitine for fatty acid transport into mitochondria. This review summarizes our present view on how FA metabolism is regulated during exercise with a special focus on the limitations in FA oxidation in the transition from moderate to high intensity exercise in humans.
U2 - 10.1113/jphysiol.2011.225011
DO - 10.1113/jphysiol.2011.225011
M3 - Review
C2 - 22271865
VL - 590
SP - 1059
EP - 1068
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 5
ER -
ID: 37588542