Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.
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Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2. / Henriksen, Dennis B; Alexandersen, Peter; Byrjalsen, Inger; Hartmann, Bolette; Bone, Henry G; Christiansen, Claus; Holst, Jens Juul.
In: Bone, Vol. 34, No. 1, 2004, p. 140-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.
AU - Henriksen, Dennis B
AU - Alexandersen, Peter
AU - Byrjalsen, Inger
AU - Hartmann, Bolette
AU - Bone, Henry G
AU - Christiansen, Claus
AU - Holst, Jens Juul
N1 - Keywords: Bone Resorption; Collagen Type I; Dose-Response Relationship, Drug; Female; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Injections, Subcutaneous; Middle Aged; Osteocalcin; Peptides; Postmenopause
PY - 2004
Y1 - 2004
N2 - We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of s-CTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC0-10 h) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05).
AB - We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of s-CTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC0-10 h) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05).
M3 - Journal article
C2 - 14751571
VL - 34
SP - 140
EP - 147
JO - Bone
JF - Bone
SN - 8756-3282
IS - 1
ER -
ID: 8418202