Reduced wall thickness of completed remodeling sites in iliac trabecular bone following anticonvulsant therapy
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Reduced wall thickness of completed remodeling sites in iliac trabecular bone following anticonvulsant therapy. / Kragstrup, J; Melsen, F; Mosekilde, L.
In: Bone, Vol. 4, No. 3, 1982, p. 181-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced wall thickness of completed remodeling sites in iliac trabecular bone following anticonvulsant therapy
AU - Kragstrup, J
AU - Melsen, F
AU - Mosekilde, L
PY - 1982
Y1 - 1982
N2 - The calcification rate and the completed wall thickness of remodeling sites in trabecular bone were estimated in undecalcified sections of tetracycline double-labeled iliac crest bone biopsies from 20 epileptic patients aged 19 to 50 years receiving long-term combined anticonvulsant therapy and 20 age- and sex-matched normal individuals. Surface distributions of thickness were obtained by a systematic equidistant sampling procedure and three-dimensional (3-D) values estimated from the two-dimensional (2-D) measurements by means of a stereologic transformation. The mean 3-D completed wall thickness was slightly reduced (P less than 0.01) in the epileptic patients (58.9 microns as compared to 62.8 microns), while no statistically significant change in the mean 3-D calcification rate (0.62 microns/day as compared to 0.64 microns/day) was found. Surface distributions of wall thickness and calcification rate were unimodal and resembled normal distributions in patients as well as in controls. The estimated duration of the formation period at remodeling sites was almost 4 months for the normal individuals and insignificantly shorter for the epileptic patients. Double determinations after 2 to 3 month intervals revealed no significant intraobserver bias in the estimates of the wall thickness or the calcification rate.
AB - The calcification rate and the completed wall thickness of remodeling sites in trabecular bone were estimated in undecalcified sections of tetracycline double-labeled iliac crest bone biopsies from 20 epileptic patients aged 19 to 50 years receiving long-term combined anticonvulsant therapy and 20 age- and sex-matched normal individuals. Surface distributions of thickness were obtained by a systematic equidistant sampling procedure and three-dimensional (3-D) values estimated from the two-dimensional (2-D) measurements by means of a stereologic transformation. The mean 3-D completed wall thickness was slightly reduced (P less than 0.01) in the epileptic patients (58.9 microns as compared to 62.8 microns), while no statistically significant change in the mean 3-D calcification rate (0.62 microns/day as compared to 0.64 microns/day) was found. Surface distributions of wall thickness and calcification rate were unimodal and resembled normal distributions in patients as well as in controls. The estimated duration of the formation period at remodeling sites was almost 4 months for the normal individuals and insignificantly shorter for the epileptic patients. Double determinations after 2 to 3 month intervals revealed no significant intraobserver bias in the estimates of the wall thickness or the calcification rate.
KW - Adult
KW - Anticonvulsants/adverse effects
KW - Bone Diseases/chemically induced
KW - Bone Resorption/chemically induced
KW - Calcinosis/chemically induced
KW - Epilepsy/drug therapy
KW - Female
KW - Humans
KW - Ilium/pathology
KW - Male
KW - Middle Aged
KW - Osteogenesis
U2 - 10.1016/0221-8747(82)90016-9
DO - 10.1016/0221-8747(82)90016-9
M3 - Journal article
C2 - 7154935
VL - 4
SP - 181
EP - 185
JO - Bone
JF - Bone
SN - 8756-3282
IS - 3
ER -
ID: 324195929