Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature
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Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering : Systematic Review of Current Literature. / Ramezanzade, Shaqayeq; Aeinehvand, Mahsa; Ziaei, Heliya; Khurshid, Zohaib; Keyhan, Seied Omid; Fallahi, Hamid R.; Melville, James C.; Saeinasab, Morvarid; Sefat, Farshid.
In: Biomimetics, Vol. 8, No. 2, 142, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering
T2 - Systematic Review of Current Literature
AU - Ramezanzade, Shaqayeq
AU - Aeinehvand, Mahsa
AU - Ziaei, Heliya
AU - Khurshid, Zohaib
AU - Keyhan, Seied Omid
AU - Fallahi, Hamid R.
AU - Melville, James C.
AU - Saeinasab, Morvarid
AU - Sefat, Farshid
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - The current review aimed to assess the reliability and efficacy of tissue-engineered composite grafts in the reconstruction of large maxillofacial defects resulting from trauma or a benign pathologic disease. A systematic review of the literature was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The eligibility criteria included patients who had been treated with composite allogeneic tissue engineering for immediate/delayed reconstruction of large maxillofacial defects with minimum/no bone harvesting site. In the initial search, 2614 papers were obtained, and finally, 13 papers were eligible to be included in the current study. Most included papers were case reports or case series. A total of 144 cases were enrolled in this systematic review. The mean age of the patients was 43.34 (age range: 9–89). Most studies reported a successful outcome. Bone tissue engineering for the reconstruction and regeneration of crucial-sized maxillofacial defects is an evolving science still in its infancy. In conclusion, this review paper and the current literature demonstrate the potential for using large-scale transplantable, vascularized, and customizable bone with the aim of reconstructing the large maxillofacial bony defects in short-term follow-ups.
AB - The current review aimed to assess the reliability and efficacy of tissue-engineered composite grafts in the reconstruction of large maxillofacial defects resulting from trauma or a benign pathologic disease. A systematic review of the literature was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The eligibility criteria included patients who had been treated with composite allogeneic tissue engineering for immediate/delayed reconstruction of large maxillofacial defects with minimum/no bone harvesting site. In the initial search, 2614 papers were obtained, and finally, 13 papers were eligible to be included in the current study. Most included papers were case reports or case series. A total of 144 cases were enrolled in this systematic review. The mean age of the patients was 43.34 (age range: 9–89). Most studies reported a successful outcome. Bone tissue engineering for the reconstruction and regeneration of crucial-sized maxillofacial defects is an evolving science still in its infancy. In conclusion, this review paper and the current literature demonstrate the potential for using large-scale transplantable, vascularized, and customizable bone with the aim of reconstructing the large maxillofacial bony defects in short-term follow-ups.
KW - composite graft
KW - maxillofacial defects
KW - tissue engineering
U2 - 10.3390/biomimetics8020142
DO - 10.3390/biomimetics8020142
M3 - Review
C2 - 37092394
AN - SCOPUS:85163807726
VL - 8
JO - Biomimetics
JF - Biomimetics
SN - 2313-7673
IS - 2
M1 - 142
ER -
ID: 361585764