Rate dependence of regional cerebral activation during performance of a repetitive motor task: a PET study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Rate dependence of regional cerebral activation during performance of a repetitive motor task : a PET study. / Blinkenberg, M; Bonde, C; Holm, S; Svarer, C; Andersen, J; Paulson, O B; Law, I.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 16, No. 5, 09.1996, p. 794-803.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Rate dependence of regional cerebral activation during performance of a repetitive motor task
T2 - a PET study
AU - Blinkenberg, M
AU - Bonde, C
AU - Holm, S
AU - Svarer, C
AU - Andersen, J
AU - Paulson, O B
AU - Law, I
PY - 1996/9
Y1 - 1996/9
N2 - Using repeated positron emission tomography (PET) measures of regional cerebral counts, we investigated the regional cortical activations induced in eight normal subjects performing eight different frequencies of fingertapping (0.5-4 Hz) with the right index finger. The task was auditorially cued and the performance recorded during the scanning procedure. Performance evaluation showed increased error rates, during fingertapping, of high and low frequencies, and the best tapping performance was measured in the midrange of frequencies. Significantly activated areas (p < 0.05) of normalized cerebral counts were located in the left sensorimotor cortex (MISI), right motor cortex, left thalamus, right insula, supplementary motor area (SMA), and bilaterally in the primary auditory cortex and the cerebellum. Statistical evaluation showed a significant (p < 0.01) and positive dependence of cerebral activation upon movement rate in the contralateral MISI. There was no significant rate dependence of cerebral activation in other activated motor areas. The SMA and the right cerebellar hemisphere showed a more uniform activation throughout the tapping frequency range. Furthermore, we found a stimulus rate dependence of cerebral activation in the primary auditory cortex. We believe that the present data provide useful information for the preparation and interpretation of future motor activation studies of normal human subjects and may serve as reference points for studies of pathological conditions.
AB - Using repeated positron emission tomography (PET) measures of regional cerebral counts, we investigated the regional cortical activations induced in eight normal subjects performing eight different frequencies of fingertapping (0.5-4 Hz) with the right index finger. The task was auditorially cued and the performance recorded during the scanning procedure. Performance evaluation showed increased error rates, during fingertapping, of high and low frequencies, and the best tapping performance was measured in the midrange of frequencies. Significantly activated areas (p < 0.05) of normalized cerebral counts were located in the left sensorimotor cortex (MISI), right motor cortex, left thalamus, right insula, supplementary motor area (SMA), and bilaterally in the primary auditory cortex and the cerebellum. Statistical evaluation showed a significant (p < 0.01) and positive dependence of cerebral activation upon movement rate in the contralateral MISI. There was no significant rate dependence of cerebral activation in other activated motor areas. The SMA and the right cerebellar hemisphere showed a more uniform activation throughout the tapping frequency range. Furthermore, we found a stimulus rate dependence of cerebral activation in the primary auditory cortex. We believe that the present data provide useful information for the preparation and interpretation of future motor activation studies of normal human subjects and may serve as reference points for studies of pathological conditions.
KW - Adult
KW - Auditory Cortex/physiology
KW - Cerebellum/physiology
KW - Cerebral Cortex/physiology
KW - Humans
KW - Kinetics
KW - Male
KW - Motor Activity/physiology
KW - Motor Cortex/physiology
KW - Regression Analysis
KW - Somatosensory Cortex/physiology
KW - Tomography, Emission-Computed
U2 - 10.1097/00004647-199609000-00004
DO - 10.1097/00004647-199609000-00004
M3 - Journal article
C2 - 8784224
VL - 16
SP - 794
EP - 803
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 5
ER -
ID: 275017853