Rapid decline in glomerular filtration rate during the first weeks following heart transplantation
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Rapid decline in glomerular filtration rate during the first weeks following heart transplantation. / Hornum, M; Andersen, M; Gustafsson, F; Oturai, Peter Sandor; Sander, K; Mortensen, S A; Feldt-Rasmussen, Bo Friis.
In: Transplantation Proceedings, Vol. 43, No. 5, 2011, p. 1904-7.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Rapid decline in glomerular filtration rate during the first weeks following heart transplantation
AU - Hornum, M
AU - Andersen, M
AU - Gustafsson, F
AU - Oturai, Peter Sandor
AU - Sander, K
AU - Mortensen, S A
AU - Feldt-Rasmussen, Bo Friis
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011
Y1 - 2011
N2 - We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.
AB - We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.
U2 - http://dx.doi.org/10.1016/j.transproceed.2011.02.065
DO - http://dx.doi.org/10.1016/j.transproceed.2011.02.065
M3 - Journal article
VL - 43
SP - 1904
EP - 1907
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 5
ER -
ID: 40151326