Rapid decline in 51Cr-EDTA measured renal function during the first weeks following lung transplantation
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Rapid decline in 51Cr-EDTA measured renal function during the first weeks following lung transplantation. / Hornum, M.; Iversen, M.; Steffensen, I.; Hovind, P.; Carlsen, J.; Andersen, L.W.; Steinbruchel, D.A.; Feldt-Rasmussen, B.
In: American Journal of Transplantation, Vol. 9, No. 6, 2009, p. 1420-1426.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Rapid decline in 51Cr-EDTA measured renal function during the first weeks following lung transplantation
AU - Hornum, M.
AU - Iversen, M.
AU - Steffensen, I.
AU - Hovind, P.
AU - Carlsen, J.
AU - Andersen, L.W.
AU - Steinbruchel, D.A.
AU - Feldt-Rasmussen, B.
PY - 2009
Y1 - 2009
N2 - We previously described a 54% decline in renal function at 6 months after lung transplantation (LTx). We hypothesized that this decline is a very early event following LTx. Thirty-one consecutive patients (16 females/15 males), mean age 49 (+/-13) years, with emphysema, cystic fibrosis/bronchiectasis or idiopathic pulmonary fibrosis were included in an analysis of renal function before and after LTx. The glomerular filtration rate (GFR) was measured using the (51)Cr-ethylenediaminetetra acetic acid plasma clearance single injection technique (mGFR) at baseline before transplantation and at 1, 2, 3 and 12 weeks postoperatively. Mean mGFR declined from 103 +/- 18 to 65 +/- 22, 53 +/- 16 and 57 +/- 18 mL/min/1.73m(2) at 1-, 3- and 12-weeks post-LTx (p < 0.0001), respectively. In a time-dependent repeated measures ANOVA, risk factors for a decline in mGFR posttransplant included: time (p < 0.0001), acute renal failure within 2 weeks post-LTx (p = 0.0003), use of heart and lung machine (p = 0.04), and the use of ephedrine (p = 0.048), as well as increasing age, older than 18 years at LTx (p = 0.006). These data demonstrate that renal function, measured with an isotope method, decreases dramatically during the first week after LTx Udgivelsesdato: 2009/6
AB - We previously described a 54% decline in renal function at 6 months after lung transplantation (LTx). We hypothesized that this decline is a very early event following LTx. Thirty-one consecutive patients (16 females/15 males), mean age 49 (+/-13) years, with emphysema, cystic fibrosis/bronchiectasis or idiopathic pulmonary fibrosis were included in an analysis of renal function before and after LTx. The glomerular filtration rate (GFR) was measured using the (51)Cr-ethylenediaminetetra acetic acid plasma clearance single injection technique (mGFR) at baseline before transplantation and at 1, 2, 3 and 12 weeks postoperatively. Mean mGFR declined from 103 +/- 18 to 65 +/- 22, 53 +/- 16 and 57 +/- 18 mL/min/1.73m(2) at 1-, 3- and 12-weeks post-LTx (p < 0.0001), respectively. In a time-dependent repeated measures ANOVA, risk factors for a decline in mGFR posttransplant included: time (p < 0.0001), acute renal failure within 2 weeks post-LTx (p = 0.0003), use of heart and lung machine (p = 0.04), and the use of ephedrine (p = 0.048), as well as increasing age, older than 18 years at LTx (p = 0.006). These data demonstrate that renal function, measured with an isotope method, decreases dramatically during the first week after LTx Udgivelsesdato: 2009/6
M3 - Journal article
VL - 9
SP - 1420
EP - 1426
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 6
ER -
ID: 19573494