Quantitative analysis of airway abnormalities in CT
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Documents
- petersen_spie_2010
Accepted author manuscript, 274 KB, PDF document
A coupled surface graph cut algorithm for airway wall segmentation from Computed Tomography (CT) images is presented. Using cost functions that highlight both inner and outer wall borders, the method combines the search for both borders into one graph cut. The proposed method is evaluated on 173 manually segmented images extracted from 15 different subjects and shown to give accurate results, with 37% less errors than the Full Width at Half Maximum (FWHM) algorithm and 62% less than a similar graph cut method without coupled surfaces. Common measures of airway wall thickness such as the Interior Area (IA) and Wall Area percentage (WA%) was measured by the proposed method on a total of 723 CT scans from a lung cancer screening study. These measures were significantly different for participants with Chronic Obstructive Pulmonary Disease (COPD) compared to asymptomatic participants. Furthermore, reproducibility was good as confirmed by repeat scans and the measures correlated well with the outcomes of pulmonary function tests, demonstrating the use of the algorithm as a COPD diagnostic tool. Additionally, a new measure of airway wall thickness is proposed, Normalized Wall Intensity Sum (NWIS). NWIS is shown to correlate better with lung function test values and to be more reproducible than previous measures IA, WA% and airway wall thickness at a lumen perimeter of 10 mm (PI10).
Original language | English |
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Title of host publication | Medical Imaging 2010 : computer-aided Diagnosis |
Editors | Nico Karssemeijer, Ronald M. Summers |
Number of pages | 12 |
Publisher | SPIE - International Society for Optical Engineering |
Publication date | 2010 |
Article number | 76241S |
ISBN (Electronic) | 9780819480255 |
DOIs | |
Publication status | Published - 2010 |
Event | Medical Imaging 2010: computer-aided diagnosis - San Diego, United States Duration: 16 Feb 2010 → 18 Feb 2010 |
Conference
Conference | Medical Imaging 2010 |
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Land | United States |
By | San Diego |
Periode | 16/02/2010 → 18/02/2010 |
Series | Progress in Biomedical Optics and Imaging |
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Number | 34 |
Volume | 11 |
ISSN | 1605-7422 |
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