Purging and accumulation of genetic load in conservation
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Purging and accumulation of genetic load in conservation. / Dussex, Nicolas; Morales, Hernán E.; Grossen, Christine; Dalén, Love; van Oosterhout, Cock.
In: Trends in Ecology and Evolution, Vol. 38, No. 10, 2023, p. 961-969.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Purging and accumulation of genetic load in conservation
AU - Dussex, Nicolas
AU - Morales, Hernán E.
AU - Grossen, Christine
AU - Dalén, Love
AU - van Oosterhout, Cock
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.
AB - Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.
KW - bottleneck
KW - conservation
KW - genetic load
KW - genomic erosion
KW - purging
U2 - 10.1016/j.tree.2023.05.008
DO - 10.1016/j.tree.2023.05.008
M3 - Journal article
C2 - 37344276
AN - SCOPUS:85162202090
VL - 38
SP - 961
EP - 969
JO - Trends in Ecology & Evolution
JF - Trends in Ecology & Evolution
SN - 0169-5347
IS - 10
ER -
ID: 358089732