TY - JOUR

T1 - Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in

T2 - The Danish High Risk and Resilience Study – VIA 7; A population-based cohort study

AU - Ellersgaard, Ditte

AU - Gregersen, Maja

AU - Spang, Katrine Soeborg

AU - Christiani, Camilla

AU - Burton, Birgitte Klee

AU - Hemager, Nicoline

AU - Søndergaard, Anne

AU - Greve, Aja

AU - Gantriis, Ditte

AU - Jepsen, Jens Richardt Møllegaard

AU - Mors, Ole

AU - Plessen, Kerstin Jessica

AU - Thorup, Anne Amalie Elgaard

AU - Nordentoft, Merete

N1 - Publisher Copyright: © 2020

PY - 2021

Y1 - 2021

N2 - We aimed to examine the prevalence of psychotic experiences (PEs) in children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and, in exploratory analyses, to examine the possible associations between PEs and mental disorders as well as level of functioning. A cohort of seven-year-old children with FHR-SZ (N = 199), FHR-BP (N = 118) and controls (N = 196) was recruited through Danish nationwide registers. Lifetime PEs were assessed through interviews using the psychosis section of the ‘Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version’ (K-SADS-PL). Lifetime DSM-IV diagnoses were ascertained through K-SADS-PL and the level of functioning of the children through ‘Children's Global Assessment Scale’. Both children with FHR-SZ (OR = 2.9, 95% CI = 1.4–6.2, p = 0.005) and FHR-BP (OR = 2.9, 95% CI = 1.3–6.7, p = 0.011) had an increased risk of having experienced “severe” PEs compared with controls. In the overall cohort PEs were associated with any lifetime mental disorder, Attention-Deficit/Hyperactivity Disorder, anxiety disorders and a lower level of functioning. The findings of a higher proportion of high risk children reporting PEs could represent an early manifestation of later more severe psychopathology or simply an unspecific transitory symptom. Future follow-up studies of this cohort will explore the predictive value of the occurrence of PEs at age seven.

AB - We aimed to examine the prevalence of psychotic experiences (PEs) in children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and, in exploratory analyses, to examine the possible associations between PEs and mental disorders as well as level of functioning. A cohort of seven-year-old children with FHR-SZ (N = 199), FHR-BP (N = 118) and controls (N = 196) was recruited through Danish nationwide registers. Lifetime PEs were assessed through interviews using the psychosis section of the ‘Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version’ (K-SADS-PL). Lifetime DSM-IV diagnoses were ascertained through K-SADS-PL and the level of functioning of the children through ‘Children's Global Assessment Scale’. Both children with FHR-SZ (OR = 2.9, 95% CI = 1.4–6.2, p = 0.005) and FHR-BP (OR = 2.9, 95% CI = 1.3–6.7, p = 0.011) had an increased risk of having experienced “severe” PEs compared with controls. In the overall cohort PEs were associated with any lifetime mental disorder, Attention-Deficit/Hyperactivity Disorder, anxiety disorders and a lower level of functioning. The findings of a higher proportion of high risk children reporting PEs could represent an early manifestation of later more severe psychopathology or simply an unspecific transitory symptom. Future follow-up studies of this cohort will explore the predictive value of the occurrence of PEs at age seven.

KW - Bipolar disorder

KW - Developmental psychopathology

KW - Familial high risk

KW - Offspring

KW - Psychotic experiences

KW - Schizophrenia

U2 - 10.1016/j.schres.2020.11.045

DO - 10.1016/j.schres.2020.11.045

M3 - Journal article

C2 - 33308959

AN - SCOPUS:85097454270

VL - 228

SP - 510

EP - 518

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -