Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect
Research output: Contribution to journal › Letter › Research › peer-review
We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.
Original language | English |
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Journal | Drug and Therapeutics Bulletin |
Volume | 61 |
Issue number | 3 |
Pages (from-to) | 44-47 |
Number of pages | 4 |
ISSN | 0012-6543 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for- profit sectors.
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
- dermatology, drugs: infectious diseases, endocrinology, hypertension, unwanted effects / adverse reactions
Research areas
ID: 396730161