Prospective relationship between occupational physical activity and risk of ischaemic heart disease: are men and women differently affected?
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Prospective relationship between occupational physical activity and risk of ischaemic heart disease : are men and women differently affected? / Allesoe, Karen; Aadahl, Mette; Jacobsen, Rikke Kart; Karhus, Line Lund; Mortensen, Ole Steen; Korshoj, Mette.
In: European Journal of Preventive Cardiology, Vol. 30, No. 9, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prospective relationship between occupational physical activity and risk of ischaemic heart disease
T2 - are men and women differently affected?
AU - Allesoe, Karen
AU - Aadahl, Mette
AU - Jacobsen, Rikke Kart
AU - Karhus, Line Lund
AU - Mortensen, Ole Steen
AU - Korshoj, Mette
PY - 2023
Y1 - 2023
N2 - Lay Summary In the Danish Monica I study among 1399 women and 1706 men, we investigated whether high physical activity at work was associated with higher risk of ischaemic heart disease and whether this association was different among men and women. The association between occupational physical activity and ischaemic heart disease was different among men and women. High physical activity at work was associated with around 45% higher risk of ischaemic heart disease in men, but with around 65% lower risk in women. The underlying mechanisms for this difference, e.g. differences in exposure and physiology, should be further investigated in future studies.Aims High occupational physical activity (OPA) seems to increase risk of cardiovascular diseases among men. However, findings are mixed, and it is not known if women are differently affected. Therefore, the aim of this study is to investigate the relationship between OPA and risk for ischaemic heart disease (IHD), and whether it differs across sex. Methods and results This prospective cohort study was based on 1399 women and 1706 men, aged 30-61 years, participating in the Danish Monica 1 study in 1982-84, actively employed, without prior IHD and answering an OPA question. The information on incidence of IHD, before and during the 34-years follow-up, was retrieved by individual linkage to the Danish National Patient Registry. Cox proportional hazards models were used to investigate the association between OPA and IHD. Compared to women with sedentary work, women in all other OPA categories had lower hazard ratio (HR) for IHD. Among men, the risk of IHD was 22% higher among those with light OPA, and 42% and 46% higher among those with moderate OPA with some lifting or strenuous work with heavy lifting, respectively, compared to men with sedentary OPA. Compared to women with sedentary work, HR for IHD was higher among men in all OPA categories. There was statistically significant interaction between OPA and sex. Conclusion Demanding or strenuous OPA seems to be a risk factor for IHD among men, whereas a higher level of OPA seems to protect women from IHD. This emphasizes the importance of taking sex differences into account in studies of health effects of OPA.
AB - Lay Summary In the Danish Monica I study among 1399 women and 1706 men, we investigated whether high physical activity at work was associated with higher risk of ischaemic heart disease and whether this association was different among men and women. The association between occupational physical activity and ischaemic heart disease was different among men and women. High physical activity at work was associated with around 45% higher risk of ischaemic heart disease in men, but with around 65% lower risk in women. The underlying mechanisms for this difference, e.g. differences in exposure and physiology, should be further investigated in future studies.Aims High occupational physical activity (OPA) seems to increase risk of cardiovascular diseases among men. However, findings are mixed, and it is not known if women are differently affected. Therefore, the aim of this study is to investigate the relationship between OPA and risk for ischaemic heart disease (IHD), and whether it differs across sex. Methods and results This prospective cohort study was based on 1399 women and 1706 men, aged 30-61 years, participating in the Danish Monica 1 study in 1982-84, actively employed, without prior IHD and answering an OPA question. The information on incidence of IHD, before and during the 34-years follow-up, was retrieved by individual linkage to the Danish National Patient Registry. Cox proportional hazards models were used to investigate the association between OPA and IHD. Compared to women with sedentary work, women in all other OPA categories had lower hazard ratio (HR) for IHD. Among men, the risk of IHD was 22% higher among those with light OPA, and 42% and 46% higher among those with moderate OPA with some lifting or strenuous work with heavy lifting, respectively, compared to men with sedentary OPA. Compared to women with sedentary work, HR for IHD was higher among men in all OPA categories. There was statistically significant interaction between OPA and sex. Conclusion Demanding or strenuous OPA seems to be a risk factor for IHD among men, whereas a higher level of OPA seems to protect women from IHD. This emphasizes the importance of taking sex differences into account in studies of health effects of OPA.
KW - Physical activity
KW - Work
KW - Heart diseases
KW - Sex differences
KW - Epidemiology
KW - CARDIOVASCULAR-DISEASE
KW - LEISURE-TIME
KW - ALL-CAUSE
KW - GENDER-DIFFERENCES
KW - 20-YEAR INCIDENCE
KW - MORTALITY
KW - WORK
KW - METAANALYSIS
KW - FITNESS
KW - HEALTH
U2 - 10.1093/eurjpc/zwad067
DO - 10.1093/eurjpc/zwad067
M3 - Journal article
C2 - 36883915
VL - 30
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
SN - 2047-4873
IS - 9
ER -
ID: 341218684