Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis. / von Essen, Marina R; Ammitzbøll, Cecilie; Hansen, Rikke H; Petersen, Eva R S; McWilliam, Oskar; Marquart, Hanne V.; Damm, Peter; Sellebjerg, Finn.

In: Brain, Vol. 142, No. 1, 2019, p. 120-132.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

von Essen, MR, Ammitzbøll, C, Hansen, RH, Petersen, ERS, McWilliam, O, Marquart, HV, Damm, P & Sellebjerg, F 2019, 'Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis', Brain, vol. 142, no. 1, pp. 120-132. https://doi.org/10.1093/brain/awy301

APA

von Essen, M. R., Ammitzbøll, C., Hansen, R. H., Petersen, E. R. S., McWilliam, O., Marquart, H. V., Damm, P., & Sellebjerg, F. (2019). Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis. Brain, 142(1), 120-132. https://doi.org/10.1093/brain/awy301

Vancouver

von Essen MR, Ammitzbøll C, Hansen RH, Petersen ERS, McWilliam O, Marquart HV et al. Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis. Brain. 2019;142(1):120-132. https://doi.org/10.1093/brain/awy301

Author

von Essen, Marina R ; Ammitzbøll, Cecilie ; Hansen, Rikke H ; Petersen, Eva R S ; McWilliam, Oskar ; Marquart, Hanne V. ; Damm, Peter ; Sellebjerg, Finn. / Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis. In: Brain. 2019 ; Vol. 142, No. 1. pp. 120-132.

Bibtex

@article{3b0a9ea1b8bb4c64bd411ed3597997eb,
title = "Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis",
abstract = "With the discovery that the highly effective anti-CD20 antibody therapies developed to deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological properties of CD20+ T cells has emerged. In this study we show that CD20+ T cells have a proinflammatory Th1/Tc1 phenotype with a high proliferative capacity to CNS antigens. We also found that the percentage of CD20+ T cells is increased in the blood of patients with multiple sclerosis and are enriched in the CSF of the patients. Furthermore, we found a positive correlation between CD20+ T cells in the CSF and multiple sclerosis disease severity and see that regulation of CD20+ T cells likely contributes to the positive treatment effect of the multiple sclerosis treatment alemtuzumab. These data represent an important contribution to the understanding of the nature of CD20+ T cells and strongly suggests a role of CD20+ T cells in the pathogenesis of multiple sclerosis.",
keywords = "Adult, Alemtuzumab/therapeutic use, Antigens, CD20/blood, Cell Proliferation/drug effects, Cytokines/metabolism, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis/blood, Multiple Sclerosis, Chronic Progressive/blood, T-Lymphocytes/drug effects, Young Adult",
author = "{von Essen}, {Marina R} and Cecilie Ammitzb{\o}ll and Hansen, {Rikke H} and Petersen, {Eva R S} and Oskar McWilliam and Marquart, {Hanne V.} and Peter Damm and Finn Sellebjerg",
year = "2019",
doi = "10.1093/brain/awy301",
language = "English",
volume = "142",
pages = "120--132",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

AU - von Essen, Marina R

AU - Ammitzbøll, Cecilie

AU - Hansen, Rikke H

AU - Petersen, Eva R S

AU - McWilliam, Oskar

AU - Marquart, Hanne V.

AU - Damm, Peter

AU - Sellebjerg, Finn

PY - 2019

Y1 - 2019

N2 - With the discovery that the highly effective anti-CD20 antibody therapies developed to deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological properties of CD20+ T cells has emerged. In this study we show that CD20+ T cells have a proinflammatory Th1/Tc1 phenotype with a high proliferative capacity to CNS antigens. We also found that the percentage of CD20+ T cells is increased in the blood of patients with multiple sclerosis and are enriched in the CSF of the patients. Furthermore, we found a positive correlation between CD20+ T cells in the CSF and multiple sclerosis disease severity and see that regulation of CD20+ T cells likely contributes to the positive treatment effect of the multiple sclerosis treatment alemtuzumab. These data represent an important contribution to the understanding of the nature of CD20+ T cells and strongly suggests a role of CD20+ T cells in the pathogenesis of multiple sclerosis.

AB - With the discovery that the highly effective anti-CD20 antibody therapies developed to deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological properties of CD20+ T cells has emerged. In this study we show that CD20+ T cells have a proinflammatory Th1/Tc1 phenotype with a high proliferative capacity to CNS antigens. We also found that the percentage of CD20+ T cells is increased in the blood of patients with multiple sclerosis and are enriched in the CSF of the patients. Furthermore, we found a positive correlation between CD20+ T cells in the CSF and multiple sclerosis disease severity and see that regulation of CD20+ T cells likely contributes to the positive treatment effect of the multiple sclerosis treatment alemtuzumab. These data represent an important contribution to the understanding of the nature of CD20+ T cells and strongly suggests a role of CD20+ T cells in the pathogenesis of multiple sclerosis.

KW - Adult

KW - Alemtuzumab/therapeutic use

KW - Antigens, CD20/blood

KW - Cell Proliferation/drug effects

KW - Cytokines/metabolism

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/blood

KW - Multiple Sclerosis, Chronic Progressive/blood

KW - T-Lymphocytes/drug effects

KW - Young Adult

U2 - 10.1093/brain/awy301

DO - 10.1093/brain/awy301

M3 - Journal article

C2 - 30561509

VL - 142

SP - 120

EP - 132

JO - Brain

JF - Brain

SN - 0006-8950

IS - 1

ER -

ID: 237654017