Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver
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Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver. / Henriksen, Jens Henrik Sahl; Lassen, N A.
In: Liver, Vol. 8, No. 2, 1988, p. 88-94.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver
AU - Henriksen, Jens Henrik Sahl
AU - Lassen, N A
N1 - Keywords: Blood Pressure; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Microcirculation; Models, Biological; Vascular Resistance
PY - 1988
Y1 - 1988
N2 - A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.
AB - A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.
M3 - Journal article
C2 - 3367712
VL - 8
SP - 88
EP - 94
JO - Liver
JF - Liver
SN - 0106-9543
IS - 2
ER -
ID: 18698170