TY - JOUR

T1 - Predictors of recovery from psychosis Analyses of clinical and social factors associated with recovery among patients with first-episode psychosis after 5 years

AU - Albert, Nikolai

AU - Bertelsen, Mette

AU - Thorup, Anne

AU - Petersen, Lone

AU - Jeppesen, Pia

AU - Le Quack, Phoung

AU - Krarup, Gertrud

AU - Jørgensen, Per

AU - Nordentoft, Merete

N1 - Copyright © 2010 Elsevier B.V. All rights reserved.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Introduction This paper aims to investigate the predictors of good outcome after first-episode non-affective psychosis and the clinical and social trajectories of those that recover. Methods A cohort of 255 patients with first-episode non-affective psychosis was interviewed 5 years after first diagnosis and treatment. Recovery was defined as working or studying, having a GAF-function score of 60 or above, having remission of negative and psychotic symptoms, and not living in a supported housing facility or being hospitalized during the last 2 years before the five-year follow-up interview. Results A total of 40 (15.7%) were found to be recovered, and 76 (29.8%) had a job or were studying after 5 years. Of those working, as many as 20 still had psychotic symptoms. Also notable is that out of the 40 recovered, less than half were recovered after 2 years. Recovery after 5 years was predicted by female sex (OR 2.4, 95% CI 1.0–5.8), higher age (OR 0.91, 95% CI 0.83–0.99), pre-morbid social adaptation (OR 0.72, 95% CI 0.56–0.93), growing up with both parents (OR 2.6, 95% CI 1.0–6.8) and low level of negative symptoms (OR 0.51, 95% CI 0.33 to 0.77) at baseline. Discussion Our findings suggest that a stable social life with normal social functioning has a predictive value for good outcome. These measures might be influenced by negative symptoms, but in the multivariate analysis with negative symptoms included they have an independent effect. Also our findings suggest that, after first-episode psychosis, some patients can still experience psychotic symptoms, but have a job and a fairly stable life.

AB - Introduction This paper aims to investigate the predictors of good outcome after first-episode non-affective psychosis and the clinical and social trajectories of those that recover. Methods A cohort of 255 patients with first-episode non-affective psychosis was interviewed 5 years after first diagnosis and treatment. Recovery was defined as working or studying, having a GAF-function score of 60 or above, having remission of negative and psychotic symptoms, and not living in a supported housing facility or being hospitalized during the last 2 years before the five-year follow-up interview. Results A total of 40 (15.7%) were found to be recovered, and 76 (29.8%) had a job or were studying after 5 years. Of those working, as many as 20 still had psychotic symptoms. Also notable is that out of the 40 recovered, less than half were recovered after 2 years. Recovery after 5 years was predicted by female sex (OR 2.4, 95% CI 1.0–5.8), higher age (OR 0.91, 95% CI 0.83–0.99), pre-morbid social adaptation (OR 0.72, 95% CI 0.56–0.93), growing up with both parents (OR 2.6, 95% CI 1.0–6.8) and low level of negative symptoms (OR 0.51, 95% CI 0.33 to 0.77) at baseline. Discussion Our findings suggest that a stable social life with normal social functioning has a predictive value for good outcome. These measures might be influenced by negative symptoms, but in the multivariate analysis with negative symptoms included they have an independent effect. Also our findings suggest that, after first-episode psychosis, some patients can still experience psychotic symptoms, but have a job and a fairly stable life.

U2 - 10.1016/j.schres.2010.10.013

DO - 10.1016/j.schres.2010.10.013

M3 - Journal article

C2 - 21056926

VL - 125

SP - 257

EP - 266

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -