Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort. / Dos Santos, Quenia; Hornum, Mads; Terrones-Campos, Cynthia; Crone, Cornelia Geisler; Wareham, Neval Ete; Soeborg, Andreas; Rasmussen, Allan; Gustafsson, Finn; Perch, Michael; Soerensen, Soeren Schwartz; Lundgren, Jens; Feldt-Rasmussen, Bo; Reekie, Joanne.

In: Transplant International, Vol. 35, 10352, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dos Santos, Q, Hornum, M, Terrones-Campos, C, Crone, CG, Wareham, NE, Soeborg, A, Rasmussen, A, Gustafsson, F, Perch, M, Soerensen, SS, Lundgren, J, Feldt-Rasmussen, B & Reekie, J 2022, 'Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort', Transplant International, vol. 35, 10352. https://doi.org/10.3389/ti.2022.10352

APA

Dos Santos, Q., Hornum, M., Terrones-Campos, C., Crone, C. G., Wareham, N. E., Soeborg, A., Rasmussen, A., Gustafsson, F., Perch, M., Soerensen, S. S., Lundgren, J., Feldt-Rasmussen, B., & Reekie, J. (2022). Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort. Transplant International, 35, [10352]. https://doi.org/10.3389/ti.2022.10352

Vancouver

Dos Santos Q, Hornum M, Terrones-Campos C, Crone CG, Wareham NE, Soeborg A et al. Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort. Transplant International. 2022;35. 10352. https://doi.org/10.3389/ti.2022.10352

Author

Dos Santos, Quenia ; Hornum, Mads ; Terrones-Campos, Cynthia ; Crone, Cornelia Geisler ; Wareham, Neval Ete ; Soeborg, Andreas ; Rasmussen, Allan ; Gustafsson, Finn ; Perch, Michael ; Soerensen, Soeren Schwartz ; Lundgren, Jens ; Feldt-Rasmussen, Bo ; Reekie, Joanne. / Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort. In: Transplant International. 2022 ; Vol. 35.

Bibtex

@article{03f05d5cea964c6db72ed0431f81d45d,

title = "Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort",

abstract = "Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46–365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46–365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16–2.69 and aHR: 1.89, 95% CI: 1.17–3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients.",

keywords = "diabetes mellitus, mortality, post-transplant diabetes mellitus, solid organ transplant recipient, transplant",

author = "{Dos Santos}, Quenia and Mads Hornum and Cynthia Terrones-Campos and Crone, {Cornelia Geisler} and Wareham, {Neval Ete} and Andreas Soeborg and Allan Rasmussen and Finn Gustafsson and Michael Perch and Soerensen, {Soeren Schwartz} and Jens Lundgren and Bo Feldt-Rasmussen and Joanne Reekie",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Dos Santos, Hornum, Terrones-Campos, Crone, Wareham, Soeborg, Rasmussen, Gustafsson, Perch, Soerensen, Lundgren, Feldt-Rasmussen and Reekie.",

year = "2022",

doi = "10.3389/ti.2022.10352",

language = "English",

volume = "35",

journal = "Transplant International",

issn = "0934-0874",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort

AU - Dos Santos, Quenia

AU - Hornum, Mads

AU - Terrones-Campos, Cynthia

AU - Crone, Cornelia Geisler

AU - Wareham, Neval Ete

AU - Soeborg, Andreas

AU - Rasmussen, Allan

AU - Gustafsson, Finn

AU - Perch, Michael

AU - Soerensen, Soeren Schwartz

AU - Lundgren, Jens

AU - Feldt-Rasmussen, Bo

AU - Reekie, Joanne

PY - 2022

Y1 - 2022

N2 - Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46–365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46–365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16–2.69 and aHR: 1.89, 95% CI: 1.17–3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients.

AB - Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46–365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46–365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16–2.69 and aHR: 1.89, 95% CI: 1.17–3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients.

KW - diabetes mellitus

KW - mortality

KW - post-transplant diabetes mellitus

KW - solid organ transplant recipient

KW - transplant

U2 - 10.3389/ti.2022.10352

DO - 10.3389/ti.2022.10352

M3 - Journal article

C2 - 35449717

AN - SCOPUS:85128503863

VL - 35

JO - Transplant International

JF - Transplant International

SN - 0934-0874

M1 - 10352

ER -

ID: 307757605

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