Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update
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Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients : An Update. / Rodríguez-Rodríguez, Ana Elena; Porrini, Esteban; Hornum, Mads; Donate-Correa, Javier; Morales-Febles, Raúl; Khemlani Ramchand, Simran; Molina Lima, Mariá Xixiang; Torres, Armando.
In: Nephron, Vol. 145, No. 4, 2021, p. 317-329.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients
T2 - An Update
AU - Rodríguez-Rodríguez, Ana Elena
AU - Porrini, Esteban
AU - Hornum, Mads
AU - Donate-Correa, Javier
AU - Morales-Febles, Raúl
AU - Khemlani Ramchand, Simran
AU - Molina Lima, Mariá Xixiang
AU - Torres, Armando
N1 - Publisher Copyright: © 2021 S. Karger AG, Basel. Copyright: All rights reserved.
PY - 2021
Y1 - 2021
N2 - Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.
AB - Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.
KW - Evolution
KW - Pathogenesis
KW - Post-transplant diabetes mellitus
KW - Prediabetes
U2 - 10.1159/000514288
DO - 10.1159/000514288
M3 - Review
C2 - 33902027
AN - SCOPUS:85105126325
VL - 145
SP - 317
EP - 329
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
SN - 1660-8151
IS - 4
ER -
ID: 304285230