Pituitary adenylate cyclase-activating peptide: Potential roles in the pathophysiology and complications of cirrhosis
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Pituitary adenylate cyclase-activating peptide : Potential roles in the pathophysiology and complications of cirrhosis. / Barloese, Mads; Chitgar, Mohammadnavid; Hannibal, Jens; Møller, Søren.
In: Liver International, Vol. 40, No. 11, 2020, p. 2578-2589.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Pituitary adenylate cyclase-activating peptide
T2 - Potential roles in the pathophysiology and complications of cirrhosis
AU - Barloese, Mads
AU - Chitgar, Mohammadnavid
AU - Hannibal, Jens
AU - Møller, Søren
N1 - Publisher Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2020
Y1 - 2020
N2 - Pituitary adenylate cyclase-activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine, including cardiology, have recently shown interest in the role of PACAP and its potential as a biomarker. Timely diagnosis and treatment of cirrhosis and its complications is a considerable challenge for health services world-wide and development of new areas of research is warranted. Direct and indirect evidence exists of PACAP involvement in the cascade of pathological events and processes ultimately leading to cirrhosis and its complications, but its exact role remains to be determined. Studies have documented PACAP involvement in immune function, metabolism, local vasoconstriction and dilatation and systemic vascular decompensation and there is ongoing research of a possible role in liver reperfusion injury. Considering these reports, PACAP could theoretically exude influence on the disease course of cirrhosis through the hypothalamus-pituitary-adrenal axis, chronic inflammation, fibrogenesis, vasodilation and reduced vascular resistance. The paucity of literature on the specific topic of PACAP and cirrhosis reflects complex mechanisms and difficulty in accurate measurements and sample taking. This does not detract from the need to further characterize and elucidate the role PACAP plays in the underdiagnosed and undertreated condition of cirrhosis.
AB - Pituitary adenylate cyclase-activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine, including cardiology, have recently shown interest in the role of PACAP and its potential as a biomarker. Timely diagnosis and treatment of cirrhosis and its complications is a considerable challenge for health services world-wide and development of new areas of research is warranted. Direct and indirect evidence exists of PACAP involvement in the cascade of pathological events and processes ultimately leading to cirrhosis and its complications, but its exact role remains to be determined. Studies have documented PACAP involvement in immune function, metabolism, local vasoconstriction and dilatation and systemic vascular decompensation and there is ongoing research of a possible role in liver reperfusion injury. Considering these reports, PACAP could theoretically exude influence on the disease course of cirrhosis through the hypothalamus-pituitary-adrenal axis, chronic inflammation, fibrogenesis, vasodilation and reduced vascular resistance. The paucity of literature on the specific topic of PACAP and cirrhosis reflects complex mechanisms and difficulty in accurate measurements and sample taking. This does not detract from the need to further characterize and elucidate the role PACAP plays in the underdiagnosed and undertreated condition of cirrhosis.
KW - cirrhosis
KW - inflammation
KW - liver
KW - pituitary adenylate cyclase-activating peptide
U2 - 10.1111/liv.14602
DO - 10.1111/liv.14602
M3 - Review
C2 - 32654367
AN - SCOPUS:85088479463
VL - 40
SP - 2578
EP - 2589
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 11
ER -
ID: 263032123