Physiology insights
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Physiology insights. / Watanabe, Richard M; Hansen, Torben.
The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer, 2016. p. 207-221.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Physiology insights
AU - Watanabe, Richard M
AU - Hansen, Torben
PY - 2016
Y1 - 2016
N2 - In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.
AB - In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.
U2 - 10.1007/978-3-319-01574-3_9
DO - 10.1007/978-3-319-01574-3_9
M3 - Book chapter
AN - SCOPUS:84978224441
SN - 978-3-319-01573-6
SP - 207
EP - 221
BT - The Genetics of Type 2 Diabetes and Related Traits
PB - Springer
ER -
ID: 179281986