Persistent Symptoms and Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection Not Requiring Hospitalization: Results From Testing Denmark, a Danish Cross-sectional Survey
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Persistent Symptoms and Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection Not Requiring Hospitalization : Results From Testing Denmark, a Danish Cross-sectional Survey. / van Wijhe, Maarten; Fogh, Kamille; Ethelberg, Steen; Iversen, Kasper Karmark; Nielsen, Henrik; Østergaard, Lars; Andersen, Berit; Bundgaard, Henning; Jorgensen, Charlotte S.; Scharff, Bibi F. S. S.; Ellermann-Eriksen, Svend; Johansen, Isik S.; Fomsgaard, Anders; Krause, Tyra Grove; Wiese, Lothar; Fischer, Thea K.; Molbak, Kare; Benfield, Thomas; Folke, Fredrik; Lippert, Freddy; Ostrowski, Sisse R.; Koch, Anders; Erikstrup, Christian; Vangsted, Anne-Marie; Sorensen, Anna Irene Vedel; Ullum, Henrik; Skov, Robert Leo; Simonsen, Lone; Nielsen, Susanne Dam.
In: Open Forum Infectious Diseases, Vol. 10, No. 1, 679, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Persistent Symptoms and Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection Not Requiring Hospitalization
T2 - Results From Testing Denmark, a Danish Cross-sectional Survey
AU - van Wijhe, Maarten
AU - Fogh, Kamille
AU - Ethelberg, Steen
AU - Iversen, Kasper Karmark
AU - Nielsen, Henrik
AU - Østergaard, Lars
AU - Andersen, Berit
AU - Bundgaard, Henning
AU - Jorgensen, Charlotte S.
AU - Scharff, Bibi F. S. S.
AU - Ellermann-Eriksen, Svend
AU - Johansen, Isik S.
AU - Fomsgaard, Anders
AU - Krause, Tyra Grove
AU - Wiese, Lothar
AU - Fischer, Thea K.
AU - Molbak, Kare
AU - Benfield, Thomas
AU - Folke, Fredrik
AU - Lippert, Freddy
AU - Ostrowski, Sisse R.
AU - Koch, Anders
AU - Erikstrup, Christian
AU - Vangsted, Anne-Marie
AU - Sorensen, Anna Irene Vedel
AU - Ullum, Henrik
AU - Skov, Robert Leo
AU - Simonsen, Lone
AU - Nielsen, Susanne Dam
PY - 2023
Y1 - 2023
N2 - Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with persistent symptoms ("long COVID"). We assessed the burden of long COVID among nonhospitalized adults with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection. Methods In the fall of 2020, a cross-sectional survey was performed in the adult Danish general population. This included a self-administered point-of-care test for SARS-CoV-2 antibodies, the Short Form Health Survey (SF-12), and coronavirus disease 2019 (COVID-19)-associated symptom questions. Nonhospitalized respondents with a positive SARS-CoV-2 PCR test >= 12 weeks before the survey (cases) were matched (1:10) to seronegative controls on age, sex, and body mass index. Propensity score-weighted odds ratios (ORs) and ORs for risk factors were estimated for each health outcome. Results In total, 742 cases and 7420 controls were included. The attributable risk of at least 1 long-COVID symptom was 25.0 per 100 cases (95% confidence interval [CI], 22.2-27.4). Compared to controls, cases reported worse general health (OR, 5.9 [95% CI, 5.0-7.0]) and had higher odds for a broad range of symptoms, particularly loss of taste (OR, 11.8 [95% CI, 9.5-14.6]) and smell (OR, 11.2 [95% CI, 9.1-13.9]). Physical and Mental Component Summary scores were also significantly reduced with differences of -2.5 (95% CI, -3.1 to -1.8) and -2.0 (95% CI, -2.7 to -1.2), respectively. Female sex and severity of initial infection were major risk factors for long COVID. Conclusions Nonhospitalized SARS-CoV-2 PCR-positive individuals had significantly reduced physical and mental health, and 1 in 4 reported persistence of at least 1 long-COVID symptom.In this national cross-sectional survey, long-COVID symptoms after SARS-CoV-2 infection are common compared to seronegative controls, affecting both physical and mental health. Female sex and severity of infection are dominant risk factors. Informed interdisciplinary management strategies for long COVID are needed.
AB - Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with persistent symptoms ("long COVID"). We assessed the burden of long COVID among nonhospitalized adults with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection. Methods In the fall of 2020, a cross-sectional survey was performed in the adult Danish general population. This included a self-administered point-of-care test for SARS-CoV-2 antibodies, the Short Form Health Survey (SF-12), and coronavirus disease 2019 (COVID-19)-associated symptom questions. Nonhospitalized respondents with a positive SARS-CoV-2 PCR test >= 12 weeks before the survey (cases) were matched (1:10) to seronegative controls on age, sex, and body mass index. Propensity score-weighted odds ratios (ORs) and ORs for risk factors were estimated for each health outcome. Results In total, 742 cases and 7420 controls were included. The attributable risk of at least 1 long-COVID symptom was 25.0 per 100 cases (95% confidence interval [CI], 22.2-27.4). Compared to controls, cases reported worse general health (OR, 5.9 [95% CI, 5.0-7.0]) and had higher odds for a broad range of symptoms, particularly loss of taste (OR, 11.8 [95% CI, 9.5-14.6]) and smell (OR, 11.2 [95% CI, 9.1-13.9]). Physical and Mental Component Summary scores were also significantly reduced with differences of -2.5 (95% CI, -3.1 to -1.8) and -2.0 (95% CI, -2.7 to -1.2), respectively. Female sex and severity of initial infection were major risk factors for long COVID. Conclusions Nonhospitalized SARS-CoV-2 PCR-positive individuals had significantly reduced physical and mental health, and 1 in 4 reported persistence of at least 1 long-COVID symptom.In this national cross-sectional survey, long-COVID symptoms after SARS-CoV-2 infection are common compared to seronegative controls, affecting both physical and mental health. Female sex and severity of infection are dominant risk factors. Informed interdisciplinary management strategies for long COVID are needed.
KW - COVID-19
KW - cross-sectional study
KW - health-related quality-of-life
KW - long COVID
KW - nonhospitalized patients
U2 - 10.1093/ofid/ofac679
DO - 10.1093/ofid/ofac679
M3 - Journal article
C2 - 36628054
VL - 10
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 1
M1 - 679
ER -
ID: 334003181