Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
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Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet. / Helge, Jørn Wulff; Watt, Peter W; Richter, Erik A; Rennie, Michael J; Kiens, Bente.
In: Journal of Applied Physiology, Vol. 93, No. 5, 2002, p. 1797-1805.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
AU - Helge, Jørn Wulff
AU - Watt, Peter W
AU - Richter, Erik A
AU - Rennie, Michael J
AU - Kiens, Bente
N1 - PUF 2002 5200 090
PY - 2002
Y1 - 2002
N2 - We tested the hypothesis that a shift to carbohydrate diet after prolonged adaptation to fat diet would lead to decreased glucose uptake and impaired muscle glycogen breakdown during exercise compared with ingestion of a carbohydrate diet all along. We studied 13 untrained men; 7 consumed a high-fat (Fat-CHO; 62% fat, 21% carbohydrate) and 6 a high-carbohydrate diet (CHO; 20% fat, 65% carbohydrate) for 7 wk, and thereafter both groups consumed the carbohydrate diet for an eighth week. Training was performed throughout. After 8 wk, during 60 min of exercise (71 +/- 1% pretraining maximal oxygen uptake) average leg glucose uptake (1.00 +/- 0.07 vs. 1.55 +/- 0.21 mmol/min) was lower (P <0.05) in Fat-CHO than in CHO. The rate of muscle glycogen breakdown was similar (4.4 +/- 0.5 vs. 4.2 +/- 0.7 mmol. min(-1). kg dry wt(-1)) despite a significantly higher preexercise glycogen concentration (872 +/- 59 vs. 688 +/- 43 mmol/kg dry wt) in Fat-CHO than in CHO. In conclusion, shift to carbohydrate diet after prolonged adaptation to fat diet and training causes increased resting muscle glycogen levels but impaired leg glucose uptake and similar muscle glycogen breakdown, despite higher resting levels, compared with when the carbohydrate diet is consumed throughout training.
AB - We tested the hypothesis that a shift to carbohydrate diet after prolonged adaptation to fat diet would lead to decreased glucose uptake and impaired muscle glycogen breakdown during exercise compared with ingestion of a carbohydrate diet all along. We studied 13 untrained men; 7 consumed a high-fat (Fat-CHO; 62% fat, 21% carbohydrate) and 6 a high-carbohydrate diet (CHO; 20% fat, 65% carbohydrate) for 7 wk, and thereafter both groups consumed the carbohydrate diet for an eighth week. Training was performed throughout. After 8 wk, during 60 min of exercise (71 +/- 1% pretraining maximal oxygen uptake) average leg glucose uptake (1.00 +/- 0.07 vs. 1.55 +/- 0.21 mmol/min) was lower (P <0.05) in Fat-CHO than in CHO. The rate of muscle glycogen breakdown was similar (4.4 +/- 0.5 vs. 4.2 +/- 0.7 mmol. min(-1). kg dry wt(-1)) despite a significantly higher preexercise glycogen concentration (872 +/- 59 vs. 688 +/- 43 mmol/kg dry wt) in Fat-CHO than in CHO. In conclusion, shift to carbohydrate diet after prolonged adaptation to fat diet and training causes increased resting muscle glycogen levels but impaired leg glucose uptake and similar muscle glycogen breakdown, despite higher resting levels, compared with when the carbohydrate diet is consumed throughout training.
KW - Adaptation, Physiological
KW - Adult
KW - Dietary Carbohydrates
KW - Dietary Fats
KW - Dose-Response Relationship, Drug
KW - Glucose
KW - Glycogen
KW - Humans
KW - Leg
KW - Male
KW - Muscle, Skeletal
KW - Osmolar Concentration
KW - Physical Education and Training
KW - Regional Blood Flow
KW - Rest
U2 - 10.1152/japplphysiol.00420.2002
DO - 10.1152/japplphysiol.00420.2002
M3 - Journal article
C2 - 12381768
VL - 93
SP - 1797
EP - 1805
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 5
ER -
ID: 139702