Pancreatic function in Crohn's disease
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Pancreatic function in Crohn's disease. / Hegnhøj, J; Hansen, C P; Rannem, T; Sobirk, H; Bjerglund Andersen, L; Andersen, Jens Rikardt.
In: Gut, Vol. 31, No. 9, 1990, p. 1076-1079.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pancreatic function in Crohn's disease
AU - Hegnhøj, J
AU - Hansen, C P
AU - Rannem, T
AU - Sobirk, H
AU - Bjerglund Andersen, L
AU - Andersen, Jens Rikardt
N1 - (Ekstern)
PY - 1990
Y1 - 1990
N2 - We investigated exocrine pancreatic function in a population of patients with Crohn's disease in order to correlate the pancreatic function with clinical and laboratory variables. A total of 143 patients affected by Crohn's disease and 115 control subjects were studied. All had a Lundh meal test. As a group patients with Crohn's disease had significantly decreased activity of both amylase (p < 0.02) and lipase (p < 0.001) in duodenal aspirates. In patients with Crohn's disease enzyme activities were not correlated to duration of disease or to extent or localisation of previous bowel resection. The lowest enzyme values were found in patients with the most extensive bowel involvement, and they were significantly lower (p < 0.05) than in patients with disease confined to the terminal ileum. The differences between enzyme values in other subgroups of patients were not significant. For the patient group as a whole no correlation was found between disease activity and enzyme values, but for the most uniform group of patients, those with terminal ileitis, pancreatic function was significantly lower (p < 0.05) in patients with moderate and severe disease compared with patients with mild disease. Thus at least two factors seem to be responsible for impaired pancreatic function in Crohn's disease: firstly disease activity and secondly localisation or extent of disease.
AB - We investigated exocrine pancreatic function in a population of patients with Crohn's disease in order to correlate the pancreatic function with clinical and laboratory variables. A total of 143 patients affected by Crohn's disease and 115 control subjects were studied. All had a Lundh meal test. As a group patients with Crohn's disease had significantly decreased activity of both amylase (p < 0.02) and lipase (p < 0.001) in duodenal aspirates. In patients with Crohn's disease enzyme activities were not correlated to duration of disease or to extent or localisation of previous bowel resection. The lowest enzyme values were found in patients with the most extensive bowel involvement, and they were significantly lower (p < 0.05) than in patients with disease confined to the terminal ileum. The differences between enzyme values in other subgroups of patients were not significant. For the patient group as a whole no correlation was found between disease activity and enzyme values, but for the most uniform group of patients, those with terminal ileitis, pancreatic function was significantly lower (p < 0.05) in patients with moderate and severe disease compared with patients with mild disease. Thus at least two factors seem to be responsible for impaired pancreatic function in Crohn's disease: firstly disease activity and secondly localisation or extent of disease.
UR - http://www.scopus.com/inward/record.url?scp=0025125117&partnerID=8YFLogxK
U2 - 10.1136/gut.31.9.1076
DO - 10.1136/gut.31.9.1076
M3 - Journal article
C2 - 1698692
AN - SCOPUS:0025125117
VL - 31
SP - 1076
EP - 1079
JO - Gut
JF - Gut
SN - 0017-5749
IS - 9
ER -
ID: 251991069