p24 as a predictor of mortality in a cohort of HIV-1-infected adults in rural Africa
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
p24 as a predictor of mortality in a cohort of HIV-1-infected adults in rural Africa. / Erikstrup, C.; Kallestrup, P.; Zinyama-Gutsire, R.B.; Gomo, E.; Luneborg-Nielsen, M.; Gerstoft, J.; Schupbach, J.; Ullum, H.; Katzenstein, T.L.
In: J A I D S, Vol. 48, No. 3, 2008, p. 345-349.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - p24 as a predictor of mortality in a cohort of HIV-1-infected adults in rural Africa
AU - Erikstrup, C.
AU - Kallestrup, P.
AU - Zinyama-Gutsire, R.B.
AU - Gomo, E.
AU - Luneborg-Nielsen, M.
AU - Gerstoft, J.
AU - Schupbach, J.
AU - Ullum, H.
AU - Katzenstein, T.L.
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Implementation of antiretroviral treatment in sub-Saharan Africa requires efficient tools to monitor HIV patients. p24 measurements have been proposed as an alternative to HIV-RNA because of the low cost of reagents and equipment needed. Here, we evaluate p24 as a prognostic marker in a cohort of HIV-1-infected individuals in Zimbabwe. METHODS: Treatment-naive HIV-1-infected individuals (n=198) from the Mupfure Schistosomiasis and HIV Cohort were followed until death or censoring (3-4.3 years). At baseline, p24, HIV-RNA, CD4 cell counts, and clinical staging (Centers for Disease Control and Prevention classification) were assessed. RESULTS: p24 correlated with HIV-RNA (P<0.0001, R: 0.44). Ten percent of p24 but only 1% of HIV-RNA measurements was undetectable. p24 predicted Centers for Disease Control and Prevention category (P<0.001) stronger than CD4 count (P=0.34) in multivariate logistic regression. p24 predicted mortality in univariate Cox analysis (P<0.0001) and in multivariate analysis, but it was inferior to HIV-RNA and CD4 count. CONCLUSIONS: This is the first study to evaluate the prognostic strength of p24 in an area with a predominance of HIV subtype C infections. p24 correlated with HIV-RNA and predicted clinical stage better than CD4 count. It predicted mortality in both univariate and multivariate analysis, but in multivariate analysis, it was inferior to HIV-RNA and CD4 count Udgivelsesdato: 2008/7/1
AB - BACKGROUND: Implementation of antiretroviral treatment in sub-Saharan Africa requires efficient tools to monitor HIV patients. p24 measurements have been proposed as an alternative to HIV-RNA because of the low cost of reagents and equipment needed. Here, we evaluate p24 as a prognostic marker in a cohort of HIV-1-infected individuals in Zimbabwe. METHODS: Treatment-naive HIV-1-infected individuals (n=198) from the Mupfure Schistosomiasis and HIV Cohort were followed until death or censoring (3-4.3 years). At baseline, p24, HIV-RNA, CD4 cell counts, and clinical staging (Centers for Disease Control and Prevention classification) were assessed. RESULTS: p24 correlated with HIV-RNA (P<0.0001, R: 0.44). Ten percent of p24 but only 1% of HIV-RNA measurements was undetectable. p24 predicted Centers for Disease Control and Prevention category (P<0.001) stronger than CD4 count (P=0.34) in multivariate logistic regression. p24 predicted mortality in univariate Cox analysis (P<0.0001) and in multivariate analysis, but it was inferior to HIV-RNA and CD4 count. CONCLUSIONS: This is the first study to evaluate the prognostic strength of p24 in an area with a predominance of HIV subtype C infections. p24 correlated with HIV-RNA and predicted clinical stage better than CD4 count. It predicted mortality in both univariate and multivariate analysis, but in multivariate analysis, it was inferior to HIV-RNA and CD4 count Udgivelsesdato: 2008/7/1
M3 - Journal article
VL - 48
SP - 345
EP - 349
JO - J A I D S
JF - J A I D S
SN - 1525-4135
IS - 3
ER -
ID: 10928067