On the pathogenesis of obesity: causal models and missing pieces of the puzzle
Research output: Contribution to journal › Review › Research › peer-review
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On the pathogenesis of obesity : causal models and missing pieces of the puzzle. / Magkos, Faidon; Sørensen, Thorkild I A; Raubenheimer, David; Dhurandhar, Nikhil V; Loos, Ruth J F; Bosy-Westphal, Anja; Clemmensen, Christoffer; Hjorth, Mads F; Allison, David B; Taubes, Gary; Ravussin, Eric; Friedman, Mark I; Hall, Kevin D; Ludwig, David S; Speakman, John R; Astrup, Arne.
In: Nature Metabolism, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - On the pathogenesis of obesity
T2 - causal models and missing pieces of the puzzle
AU - Magkos, Faidon
AU - Sørensen, Thorkild I A
AU - Raubenheimer, David
AU - Dhurandhar, Nikhil V
AU - Loos, Ruth J F
AU - Bosy-Westphal, Anja
AU - Clemmensen, Christoffer
AU - Hjorth, Mads F
AU - Allison, David B
AU - Taubes, Gary
AU - Ravussin, Eric
AU - Friedman, Mark I
AU - Hall, Kevin D
AU - Ludwig, David S
AU - Speakman, John R
AU - Astrup, Arne
N1 - © 2024. Springer Nature Limited.
PY - 2024
Y1 - 2024
N2 - Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate-insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a recent workshop in Copenhagen that brought together obesity experts from around the world to discuss causal models of obesity pathogenesis. These discussions helped to operationally define commonly used terms; delineate the structure of each model, particularly focussing on areas of overlap and divergence; challenge ideas about the importance of purported causal factors for weight gain; and brainstorm on the key scientific questions that need to be answered. We hope that more experimental research in nutrition and other related fields, and more testing of the models and their predictions will pave the way and provide more answers about the pathogenesis of obesity than those currently available.
AB - Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate-insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a recent workshop in Copenhagen that brought together obesity experts from around the world to discuss causal models of obesity pathogenesis. These discussions helped to operationally define commonly used terms; delineate the structure of each model, particularly focussing on areas of overlap and divergence; challenge ideas about the importance of purported causal factors for weight gain; and brainstorm on the key scientific questions that need to be answered. We hope that more experimental research in nutrition and other related fields, and more testing of the models and their predictions will pave the way and provide more answers about the pathogenesis of obesity than those currently available.
U2 - 10.1038/s42255-024-01106-8
DO - 10.1038/s42255-024-01106-8
M3 - Review
C2 - 39164418
JO - Nature Metabolism
JF - Nature Metabolism
SN - 2522-5812
ER -
ID: 402638497