Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
Research output: Contribution to journal › Journal article › Research › peer-review
Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.
| Original language | English |
|---|---|
| Journal | Journal of Neuroimmunology |
| Volume | 274 |
| Issue number | 1-2 |
| Pages (from-to) | 174-179 |
| Number of pages | 6 |
| ISSN | 0165-5728 |
| DOIs | |
| Publication status | Published - 15 Sep 2014 |
- Adult, Female, HLA-DRB1 Chains, Haplotypes, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Killer Cells, Natural, Ligands, Male, Multiple Sclerosis, Relapsing-Remitting, Oligoclonal Bands, Phenotype, Receptors, KIR2DL1, Receptors, KIR2DL2, Receptors, KIR2DL3, Registries
Research areas
ID: 137965363