Odor identification in 7-year-old children at familial high risk of schizophrenia or bipolar disorder - the Danish high risk and resilience study VIA 7
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Odor identification in 7-year-old children at familial high risk of schizophrenia or bipolar disorder - the Danish high risk and resilience study VIA 7. / Ver Loren van Themaat, Anna Hester; Uddin, Md Jamal; Christiani, Camilla Jerlang; Hemager, Nicoline; Ellersgaard, Ditte; Klee Burton, Birgitte; Spang, Katrine Søborg; Greve, Aja; Gantriis, Ditte; Mors, Ole; Elgaard Thorup, Anne Amalie; Plessen, Kerstin Jessica; Nordentoft, Merete; Møllegaard Jepsen, Jens Richardt.
In: Schizophrenia Research, Vol. 216, 2020, p. 77-84.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Odor identification in 7-year-old children at familial high risk of schizophrenia or bipolar disorder - the Danish high risk and resilience study VIA 7
AU - Ver Loren van Themaat, Anna Hester
AU - Uddin, Md Jamal
AU - Christiani, Camilla Jerlang
AU - Hemager, Nicoline
AU - Ellersgaard, Ditte
AU - Klee Burton, Birgitte
AU - Spang, Katrine Søborg
AU - Greve, Aja
AU - Gantriis, Ditte
AU - Mors, Ole
AU - Elgaard Thorup, Anne Amalie
AU - Plessen, Kerstin Jessica
AU - Nordentoft, Merete
AU - Møllegaard Jepsen, Jens Richardt
PY - 2020
Y1 - 2020
N2 - Background: Odor identification deficits occur in individuals with schizophrenia and their unaffected first-degree relatives, while deficits are less pronounced in individuals with bipolar disorder. We hypothesized that children at familial high-risk for schizophrenia (FHR-SZ) show odor identification deficits compared to population-based controls and that children at familial high-risk for bipolar disorder (FHR-BP) perform intermediate. Methods: Odor identification was assessed at age 7 in 184 children with FHR-SZ, 106 children with FHR-BP, and 186 population-based controls with the Brief Smell Identification Test. Dimensional and predefined categorical outcomes were used in the analyses. Potential relationships with psychopathological, cognitive, and home environmental variables were conducted using hierarchical and logistic multiple regression analyses. Results: ANOVA revealed no between-group differences in odor identification. Using the recommended cut-off (below 5), we found a significantly greater proportion of boys at FHR-SZ than population-based boys with an abnormal odor identification (p = .013). However, a supplementary analysis using a Danish-based cut-off (below 4) did not support this. All children showed significant, positive associations of odor identification with female gender, social responsiveness, and verbal working memory. Lower social responsiveness predicted abnormal odor identification in boys at FHR-SZ, only using the recommended cut-off. Conclusions: Odor identification efficacy and risk status appear independent in this early developmental phase. Using the recommended threshold, abnormal odor identification is more frequent in young boys at FHR-SZ than in population-based boys and is linked to lower social responsiveness. The validity of these results is questioned by non-significant differences in the rates when using an exploratory Danish-based threshold.
AB - Background: Odor identification deficits occur in individuals with schizophrenia and their unaffected first-degree relatives, while deficits are less pronounced in individuals with bipolar disorder. We hypothesized that children at familial high-risk for schizophrenia (FHR-SZ) show odor identification deficits compared to population-based controls and that children at familial high-risk for bipolar disorder (FHR-BP) perform intermediate. Methods: Odor identification was assessed at age 7 in 184 children with FHR-SZ, 106 children with FHR-BP, and 186 population-based controls with the Brief Smell Identification Test. Dimensional and predefined categorical outcomes were used in the analyses. Potential relationships with psychopathological, cognitive, and home environmental variables were conducted using hierarchical and logistic multiple regression analyses. Results: ANOVA revealed no between-group differences in odor identification. Using the recommended cut-off (below 5), we found a significantly greater proportion of boys at FHR-SZ than population-based boys with an abnormal odor identification (p = .013). However, a supplementary analysis using a Danish-based cut-off (below 4) did not support this. All children showed significant, positive associations of odor identification with female gender, social responsiveness, and verbal working memory. Lower social responsiveness predicted abnormal odor identification in boys at FHR-SZ, only using the recommended cut-off. Conclusions: Odor identification efficacy and risk status appear independent in this early developmental phase. Using the recommended threshold, abnormal odor identification is more frequent in young boys at FHR-SZ than in population-based boys and is linked to lower social responsiveness. The validity of these results is questioned by non-significant differences in the rates when using an exploratory Danish-based threshold.
KW - Endophenotype
KW - Neurodevelopment
KW - Offspring
KW - Olfactory functioning
U2 - 10.1016/j.schres.2019.12.028
DO - 10.1016/j.schres.2019.12.028
M3 - Journal article
C2 - 31924376
AN - SCOPUS:85077663413
VL - 216
SP - 77
EP - 84
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 242708127