Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment
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Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment. / Filteau, Suzanne; PrayGod, G; Woodd, Susannah L; Friis, Henrik; Heimburger, Douglas C; Koethe, John R; Kelly, P; Kasonka, Lackson; Rehman, Andrea M.
In: Tropical Medicine & International Health, Vol. 22, No. 10, 2017, p. 1302-1313.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment
AU - Filteau, Suzanne
AU - PrayGod, G
AU - Woodd, Susannah L
AU - Friis, Henrik
AU - Heimburger, Douglas C
AU - Koethe, John R
AU - Kelly, P
AU - Kasonka, Lackson
AU - Rehman, Andrea M
N1 - CURIS 2017 NEXS 223
PY - 2017
Y1 - 2017
N2 - OBJECTIVES: Low grip strength is a marker of frailty and a risk factor for mortality among HIV patients and other populations. We investigated factors associated with grip strength in malnourished HIV patients at referral to ART, and at 12 weeks and 2-3 years after starting ART.METHODS: The study involved HIV-infected Zambian and Tanzanian participants recruited to the NUSTART trial when malnourished (body mass index <18.5 kg/m(2) ) and requiring ART. The relationship of grip strength to nutritional, infectious and demographic factors was assessed by multivariable linear regression at referral for ART (n=1742) and after 12 weeks (n=778) and 2-3 years of ART (n=273).RESULTS: In analyses controlled only for sex, age and height, most nutrition and infection-related variables were associated with grip strength. However, in multivariable analyses, consistent associations were seen for fat-free mass index, mid-upper arm circumference, haemoglobin and systolic blood pressure, and a variable association with fat mass index in men. C-reactive protein and CD4 count had limited independent effects on grip strength, while receiving tuberculosis treatment was associated with weaker grip strength.CONCLUSIONS: In this population of originally malnourished HIV patients, poor grip strength was more strongly and independently associated with nutritional than with infection and inflammation variables. Programmes to improve health and survival of HIV patients should incorporate nutritional assessment and management and could use grip strength as a functional indicator of improving nutrition. This article is protected by copyright. All rights reserved.
AB - OBJECTIVES: Low grip strength is a marker of frailty and a risk factor for mortality among HIV patients and other populations. We investigated factors associated with grip strength in malnourished HIV patients at referral to ART, and at 12 weeks and 2-3 years after starting ART.METHODS: The study involved HIV-infected Zambian and Tanzanian participants recruited to the NUSTART trial when malnourished (body mass index <18.5 kg/m(2) ) and requiring ART. The relationship of grip strength to nutritional, infectious and demographic factors was assessed by multivariable linear regression at referral for ART (n=1742) and after 12 weeks (n=778) and 2-3 years of ART (n=273).RESULTS: In analyses controlled only for sex, age and height, most nutrition and infection-related variables were associated with grip strength. However, in multivariable analyses, consistent associations were seen for fat-free mass index, mid-upper arm circumference, haemoglobin and systolic blood pressure, and a variable association with fat mass index in men. C-reactive protein and CD4 count had limited independent effects on grip strength, while receiving tuberculosis treatment was associated with weaker grip strength.CONCLUSIONS: In this population of originally malnourished HIV patients, poor grip strength was more strongly and independently associated with nutritional than with infection and inflammation variables. Programmes to improve health and survival of HIV patients should incorporate nutritional assessment and management and could use grip strength as a functional indicator of improving nutrition. This article is protected by copyright. All rights reserved.
KW - HIV
KW - Antiretroviral therapy
KW - Grip strength
KW - Nutrition
KW - Inflammation
U2 - 10.1111/tmi.12929
DO - 10.1111/tmi.12929
M3 - Journal article
C2 - 28712113
VL - 22
SP - 1302
EP - 1313
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
IS - 10
ER -
ID: 181936078