Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa
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Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa. / Ring, Hans Christian; Bay, Lene; Kallenbach, Klaus; Miller, Iben M.; Prens, Errol; Saunte, Ditte M.; Bjarnsholt, Thomas; Jemec, Gregor B. E.
In: Acta Dermato-Venereologica, Vol. 97, No. 2, 02.2017, p. 208-213.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa
AU - Ring, Hans Christian
AU - Bay, Lene
AU - Kallenbach, Klaus
AU - Miller, Iben M.
AU - Prens, Errol
AU - Saunte, Ditte M.
AU - Bjarnsholt, Thomas
AU - Jemec, Gregor B. E.
PY - 2017/2
Y1 - 2017/2
N2 - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginousregions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesizedthat clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differenceswere found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthycontrols. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.
AB - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginousregions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesizedthat clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differenceswere found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthycontrols. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.
KW - hidradenitis suppurativa
KW - microbiota
KW - biofilm
KW - preclinical
U2 - 10.2340/00015555-2503
DO - 10.2340/00015555-2503
M3 - Journal article
C2 - 27377144
VL - 97
SP - 208
EP - 213
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 2
ER -
ID: 174662470