Neuro-SPECT:On the development and function of brain emission tomography in the Copenhagen area
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Neuro-SPECT:On the development and function of brain emission tomography in the Copenhagen area. / Lassen, Anders; Stokely, Ernest; Vorstrup, Sissel; Goldman, Tomasz; Henriksen, Jens H.
In: Clinical Physiology and Functional Imaging, Vol. 41, No. 1, 2021, p. 10-24.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Neuro-SPECT:On the development and function of brain emission tomography in the Copenhagen area
AU - Lassen, Anders
AU - Stokely, Ernest
AU - Vorstrup, Sissel
AU - Goldman, Tomasz
AU - Henriksen, Jens H.
PY - 2021
Y1 - 2021
N2 - This review describes the development of single-photon emission tomography (SPECT) in the Copenhagen area under the leadership of the internationally renown scientist, Niels A. Lassen, and the history leading up to construction of the tomograph. Measurements of global cerebral blood flow (CBF) in the 1940s and 1950s were performed by Kety & Schmidt and Lassen & Munck. Determination of regional cerebral blood flow (rCBF) by intra-arterial injection of 133Xe and measurement with a 254-multicrystal scintillation detector and a computer system was a major step forward in the study of physiology and pathophysiology of cortical cerebral blood flow. Tomography with radioisotope ligands, including non-invasive administration, was advanced in different centres during the 1970s. An emission tomograph, the Tomomatic 64, was developed as a result of a multidisciplinary Danish and international collaboration. It was the first emission tomograph to provide dynamic data that could produce cross-sectional rCBF images. The present description of the construction and function of the Tomomatic 64 includes comparison with other contemporary and later brain-dedicated SPECT systems. Basic and clinical application of the Tomomatic 64 in Copenhagen resulted in several hundred important scientific publications and improved diagnostics for patients with a variety of neurological disorders. It is concluded that the development of the Tomomatic 64 was a major step forward in the study and examination of rCBF and brain function related to several brain disorders, in addition to vascular diseases.
AB - This review describes the development of single-photon emission tomography (SPECT) in the Copenhagen area under the leadership of the internationally renown scientist, Niels A. Lassen, and the history leading up to construction of the tomograph. Measurements of global cerebral blood flow (CBF) in the 1940s and 1950s were performed by Kety & Schmidt and Lassen & Munck. Determination of regional cerebral blood flow (rCBF) by intra-arterial injection of 133Xe and measurement with a 254-multicrystal scintillation detector and a computer system was a major step forward in the study of physiology and pathophysiology of cortical cerebral blood flow. Tomography with radioisotope ligands, including non-invasive administration, was advanced in different centres during the 1970s. An emission tomograph, the Tomomatic 64, was developed as a result of a multidisciplinary Danish and international collaboration. It was the first emission tomograph to provide dynamic data that could produce cross-sectional rCBF images. The present description of the construction and function of the Tomomatic 64 includes comparison with other contemporary and later brain-dedicated SPECT systems. Basic and clinical application of the Tomomatic 64 in Copenhagen resulted in several hundred important scientific publications and improved diagnostics for patients with a variety of neurological disorders. It is concluded that the development of the Tomomatic 64 was a major step forward in the study and examination of rCBF and brain function related to several brain disorders, in addition to vascular diseases.
KW - brain function
KW - brain-dedicated SPECT systems
KW - global cerebral blood flow
KW - regional cerebral blood flow
KW - single-photon emission tomography
U2 - 10.1111/cpf.12663
DO - 10.1111/cpf.12663
M3 - Review
C2 - 32956526
AN - SCOPUS:85092481849
VL - 41
SP - 10
EP - 24
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
SN - 1475-0961
IS - 1
ER -
ID: 250817922