Neurocognitive heterogeneity in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study - VIA 7
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Neurocognitive heterogeneity in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study - VIA 7. / Hemager, Nicoline; Christiani, Camilla Jerlang; Thorup, Anne Amalie Elgaard; Spang, Katrine Søborg; Ellersgaard, Ditte; Burton, Birgitte Klee; Gregersen, Maja; Greve, Aja Neergaard; Wang, Yunpeng; Nudel, Ron; Mors, Ole; Plessen, Kerstin Jessica; Nordentoft, Merete; Jepsen, Jens Richardt Møllegaard.
In: Journal of Affective Disorders, Vol. 302, 2022, p. 214-223.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neurocognitive heterogeneity in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study - VIA 7
AU - Hemager, Nicoline
AU - Christiani, Camilla Jerlang
AU - Thorup, Anne Amalie Elgaard
AU - Spang, Katrine Søborg
AU - Ellersgaard, Ditte
AU - Burton, Birgitte Klee
AU - Gregersen, Maja
AU - Greve, Aja Neergaard
AU - Wang, Yunpeng
AU - Nudel, Ron
AU - Mors, Ole
AU - Plessen, Kerstin Jessica
AU - Nordentoft, Merete
AU - Jepsen, Jens Richardt Møllegaard
PY - 2022
Y1 - 2022
N2 - BackgroundStudies of neurocognitive heterogeneity in young children at familial high-risk of bipolar disorder (FHR-BP) or schizophrenia (FHR-SZ) are important to investigate inter-individual neurocognitive differences. We aimed to identify neurocognitive subgroups, describe prevalence of FHR-BP or FHR-SZ children herein, and examine risk ratios (RR) compared with controls.MethodsIn a population-based cohort of 514 7-year-old children (197 FHR-SZ, 118 FHR-BP, and 199 matched controls) we used hierarchical cluster analyses to identify subgroups across 14 neurocognitive indices.ResultsThree neurocognitive subgroups were derived: A Mildly Impaired (30%), Typical (51%), and Above Average subgroup (19%). The Mildly Impaired subgroup significantly underperformed controls (Cohen d = 0.11–1.45; Ps < 0.001) except in set-shifting (P = .84). FHR-SZ children were significantly more prevalent in the Mildly Impaired subgroup; FHR-BP children were more so in the Above Average subgroup (X2 (2, N = 315) = 9.64, P < .01). 79.7% FHR-BP and 64.6% FHR-SZ children demonstrated typical or above average neurocognitive functions. Neurocognitive heterogeneity related significantly to concurrent functioning, psychopathology severity, home environment adequacy, and polygenic scores for schizophrenia (Ps <. 01). Compared with controls, FHR-SZ and FHR-BP children had a 93% (RR, 1.93; 95% CI, 1.40–2.64) and 8% (RR, 1.08; 95% CI, 0.71–1.66) increased risk of Mildly Impaired subgroup membership.LimitationsLimitations include the cross-sectional design and smaller FHR-BP sample size.ConclusionsIdentification of neurocognitive heterogeneity in preadolescent children at FHR-BP or FHR-SZ may ease stigma and enable pre-emptive interventions to enhance neurocognitive functioning and resilience to mental illness in the impaired sub-population.
AB - BackgroundStudies of neurocognitive heterogeneity in young children at familial high-risk of bipolar disorder (FHR-BP) or schizophrenia (FHR-SZ) are important to investigate inter-individual neurocognitive differences. We aimed to identify neurocognitive subgroups, describe prevalence of FHR-BP or FHR-SZ children herein, and examine risk ratios (RR) compared with controls.MethodsIn a population-based cohort of 514 7-year-old children (197 FHR-SZ, 118 FHR-BP, and 199 matched controls) we used hierarchical cluster analyses to identify subgroups across 14 neurocognitive indices.ResultsThree neurocognitive subgroups were derived: A Mildly Impaired (30%), Typical (51%), and Above Average subgroup (19%). The Mildly Impaired subgroup significantly underperformed controls (Cohen d = 0.11–1.45; Ps < 0.001) except in set-shifting (P = .84). FHR-SZ children were significantly more prevalent in the Mildly Impaired subgroup; FHR-BP children were more so in the Above Average subgroup (X2 (2, N = 315) = 9.64, P < .01). 79.7% FHR-BP and 64.6% FHR-SZ children demonstrated typical or above average neurocognitive functions. Neurocognitive heterogeneity related significantly to concurrent functioning, psychopathology severity, home environment adequacy, and polygenic scores for schizophrenia (Ps <. 01). Compared with controls, FHR-SZ and FHR-BP children had a 93% (RR, 1.93; 95% CI, 1.40–2.64) and 8% (RR, 1.08; 95% CI, 0.71–1.66) increased risk of Mildly Impaired subgroup membership.LimitationsLimitations include the cross-sectional design and smaller FHR-BP sample size.ConclusionsIdentification of neurocognitive heterogeneity in preadolescent children at FHR-BP or FHR-SZ may ease stigma and enable pre-emptive interventions to enhance neurocognitive functioning and resilience to mental illness in the impaired sub-population.
U2 - 10.1016/j.jad.2022.01.096
DO - 10.1016/j.jad.2022.01.096
M3 - Journal article
C2 - 35085674
VL - 302
SP - 214
EP - 223
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 321267412