Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
Research output: Contribution to journal › Journal article › Research › peer-review
β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
Original language | English |
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Journal | Circulation |
Volume | 125 |
Issue number | 16 |
Pages (from-to) | 1988-96 |
Number of pages | 9 |
ISSN | 0009-7322 |
DOIs | |
Publication status | Published - 24 Apr 2012 |
- Adolescent, Adrenergic beta-Antagonists, Adult, Child, Female, Genetic Predisposition to Disease, Heart Arrest, Humans, KCNQ1 Potassium Channel, Male, Mutation, Risk, Romano-Ward Syndrome, Treatment Outcome, Young Adult
Research areas
ID: 48052006