Muscle Function Tests as Supportive Outcome Measures for Performance-Based and Self-Reported Physical Function in Patients with Knee Osteoarthritis: Exploratory Analysis of Baseline Data from a Randomized Trial
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Holm, PM, Kemnitz, J, Bandholm, T, Wernbom, M, Schrøder, HM, and Skou, ST. Muscle function tests as supportive outcome measures for performance-based and self-reported physical function in patients with knee osteoarthritis: Exploratory analysis of baseline data from a randomized trial. J Strength Cond Res 36(9): 2635-2642, 2022-Uncertainty on the role of muscle function in relation to physical function in knee osteoarthritis (KOA) persists. This study aimed to assess the associations between muscle function and performance-based and self-reported physical function in patients with KOA. Physical function in 80 subjects with symptomatic and radiographic KOA was assessed using 40-m fast-paced walk, 30-second chair stand, 9-step stair climb tests, and the subscale activities of daily living from the Knee injury and Osteoarthritis Outcome Score (KOOS-ADL). Measurements of muscle function included leg extension (LE) power, knee extension (KE) torque, and estimated leg press one repetition maximum (LP RM). Associations were investigated using multivariable hierarchical linear regressions adjusted for age, sex, body mass index, self-reported physical activity, and thigh muscle lean area. Leg extension power was significantly associated with 40-m walk, stair climb, and 30-second chair stand, explaining 18, 8, and 3% of additional variance, respectively. Knee extension torque explained 13, 7, 17, and 7% of additional variance in the 40-m walk, stair climb, 30-second chair stand, and KOOS-ADL, respectively. Leg press one repetition maximum explained 11% of additional variance in the 30-second chair stand. In conclusion, LE power was the best explanatory variable for performance on the 40-m walk and stair climb tests, whereas KE torque best explained chair stand performance. Only KE torque was associated with KOOS-ADL. Our results highlight the importance of selecting supportive muscle function tests based on the specific physical function and suggest that other factors may be more important for certain physical function outcomes. Level of significance p < 0.05. Trial identifier: NCT03215602.
Original language | English |
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Journal | Journal of Strength and Conditioning Research |
Volume | 36 |
Issue number | 9 |
Pages (from-to) | 2635-2642 |
ISSN | 1064-8011 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Funding Information:
The authors are thankful for the shift put in by project staff and collaborators, making this work possible. The authors are also thankful for the financial support provided for the randomized trial by the Danish Rheumatism Association, the Regional Health Research Grant of Region Zealand, and Næstved-Slagelse-Ringsted Hospitals Research Grant. P. M. Holm is funded by a postdoc grant from Clinical Academic Group (CAG) — Research Osteoarthritis Denmark (ROAD) and a grant from Region Zealand (Exercise First). S. T. Skou is currently funded by a grant from Region Zealand (Exercise First) and a grant from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 801790). The funders did not have any involvement in the study other than providing funding. S. T. Skou is associate editor of the Journal of Orthopaedic & Sports Physical Therapy, has received grants from the Lundbeck Foundation, personal fees from Munksgaard, all of which are outside the submitted work. He is cofounder of Good Life with Osteoarthritis in Denmark (GLA: D), a not-for profit initiative hosted at University of Southern Denmark aimed at implementing clinical guidelines for osteoarthritis in clinical practice. The authors affirm that they have no financial affiliation (including research funding) or involvement with any commercial organization that has a direct financial interest in any matter included in this manuscript, except as disclosed in an attachment and cited in the manuscript.
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