Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system
Research output: Contribution to journal › Journal article › Research
T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
Original language | English |
---|---|
Journal | Journal of Neuroimmunology |
Volume | 127 |
Issue number | 1-2 |
Pages (from-to) | 59-68 |
Number of pages | 10 |
ISSN | 0165-5728 |
Publication status | Published - Jun 2002 |
- Adult, Aged, Astrocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Central Nervous System, Cerebrospinal Fluid, Chemokine CXCL10, Chemokines, CXC, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis, Myelitis, Transverse, Optic Neuritis, Receptors, CXCR3, Receptors, Chemokine
Research areas
ID: 111410582