Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. / Pedersen, Karin K; Manner, Ingjerd W; Seljeflot, Ingebjørg; Kvale, Dag; Os, Ingrid; Gerstoft, Jan; Nielsen, Susanne D; Trøseid, Marius.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 67, No. 4, 01.12.2014, p. 370-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, KK, Manner, IW, Seljeflot, I, Kvale, D, Os, I, Gerstoft, J, Nielsen, SD & Trøseid, M 2014, 'Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART', Journal of acquired immune deficiency syndromes (1999), vol. 67, no. 4, pp. 370-4. https://doi.org/10.1097/QAI.0000000000000339

APA

Pedersen, K. K., Manner, I. W., Seljeflot, I., Kvale, D., Os, I., Gerstoft, J., Nielsen, S. D., & Trøseid, M. (2014). Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. Journal of acquired immune deficiency syndromes (1999), 67(4), 370-4. https://doi.org/10.1097/QAI.0000000000000339

Vancouver

Pedersen KK, Manner IW, Seljeflot I, Kvale D, Os I, Gerstoft J et al. Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. Journal of acquired immune deficiency syndromes (1999). 2014 Dec 1;67(4):370-4. https://doi.org/10.1097/QAI.0000000000000339

Author

Pedersen, Karin K ; Manner, Ingjerd W ; Seljeflot, Ingebjørg ; Kvale, Dag ; Os, Ingrid ; Gerstoft, Jan ; Nielsen, Susanne D ; Trøseid, Marius. / Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. In: Journal of acquired immune deficiency syndromes (1999). 2014 ; Vol. 67, No. 4. pp. 370-4.

Bibtex

@article{52a95ae3fcaf4893bde6db5192b54bce,
title = "Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART",
abstract = "BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.",
keywords = "Adult, Aged, Anti-HIV Agents, Antigens, CD14, Antiretroviral Therapy, Highly Active, Arginine, Bacterial Translocation, Biological Markers, Cardiovascular Diseases, Female, Fibrin Fibrinogen Degradation Products, HIV Infections, Humans, Lipopolysaccharides, Male, Middle Aged, Monocytes",
author = "Pedersen, {Karin K} and Manner, {Ingjerd W} and Ingebj{\o}rg Seljeflot and Dag Kvale and Ingrid Os and Jan Gerstoft and Nielsen, {Susanne D} and Marius Tr{\o}seid",
year = "2014",
month = dec,
day = "1",
doi = "10.1097/QAI.0000000000000339",
language = "English",
volume = "67",
pages = "370--4",
journal = "J A I D S",
issn = "1525-4135",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

AU - Pedersen, Karin K

AU - Manner, Ingjerd W

AU - Seljeflot, Ingebjørg

AU - Kvale, Dag

AU - Os, Ingrid

AU - Gerstoft, Jan

AU - Nielsen, Susanne D

AU - Trøseid, Marius

PY - 2014/12/1

Y1 - 2014/12/1

N2 - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

AB - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

KW - Adult

KW - Aged

KW - Anti-HIV Agents

KW - Antigens, CD14

KW - Antiretroviral Therapy, Highly Active

KW - Arginine

KW - Bacterial Translocation

KW - Biological Markers

KW - Cardiovascular Diseases

KW - Female

KW - Fibrin Fibrinogen Degradation Products

KW - HIV Infections

KW - Humans

KW - Lipopolysaccharides

KW - Male

KW - Middle Aged

KW - Monocytes

U2 - 10.1097/QAI.0000000000000339

DO - 10.1097/QAI.0000000000000339

M3 - Journal article

C2 - 25226210

VL - 67

SP - 370

EP - 374

JO - J A I D S

JF - J A I D S

SN - 1525-4135

IS - 4

ER -

ID: 137203126