Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise
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Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise. / Lundsgaard, Annemarie; Fritzen, Andreas Mæchel; Kiens, Bente.
In: Trends in Endocrinology and Metabolism, Vol. 29, No. 1, 2018, p. 18-30.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise
AU - Lundsgaard, Annemarie
AU - Fritzen, Andreas Mæchel
AU - Kiens, Bente
N1 - CURIS 2018 NEXS 010
PY - 2018
Y1 - 2018
N2 - This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during exercise. From the available evidence it seems that acetyl-CoA availability in the mitochondrial matrix adjusts FA oxidation to exercise intensity and duration. This is executed at the step of mitochondrial fatty acyl import, as the extent of acetyl group sequestration by carnitine determines the availability of carnitine for the carnitine palmitoyltransferase 1 (CPT1) reaction. The rate of glycolysis seems therefore to be central to the amount of β-oxidation-derived acetyl-CoA that is oxidized in the tricarboxylic acid (TCA) cycle. FA oxidation during exercise is also determined by FA availability to mitochondria, dependent on trans-sarcolemmal FA uptake via cluster of differentiation 36/SR-B2 (CD36) and FAs mobilized from myocellular lipid droplets.
AB - This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during exercise. From the available evidence it seems that acetyl-CoA availability in the mitochondrial matrix adjusts FA oxidation to exercise intensity and duration. This is executed at the step of mitochondrial fatty acyl import, as the extent of acetyl group sequestration by carnitine determines the availability of carnitine for the carnitine palmitoyltransferase 1 (CPT1) reaction. The rate of glycolysis seems therefore to be central to the amount of β-oxidation-derived acetyl-CoA that is oxidized in the tricarboxylic acid (TCA) cycle. FA oxidation during exercise is also determined by FA availability to mitochondria, dependent on trans-sarcolemmal FA uptake via cluster of differentiation 36/SR-B2 (CD36) and FAs mobilized from myocellular lipid droplets.
KW - Glycolysis
KW - Pyruvate dehydrogenase
KW - Acetyl-CoA
KW - Carnitine palmitoyltransferase 1
KW - Carnitine acyltransferase
U2 - 10.1016/j.tem.2017.10.011
DO - 10.1016/j.tem.2017.10.011
M3 - Review
C2 - 29221849
VL - 29
SP - 18
EP - 30
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 1
ER -
ID: 186648654