Molecular and cellular physiology of sodium-dependent glutamate transporters

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Molecular and cellular physiology of sodium-dependent glutamate transporters. / Rose, Christine R; Ziemens, Daniel; Untiet, Verena; Fahlke, Christoph.

In: Brain Research Bulletin, Vol. 136, 2018, p. 3-16.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rose, CR, Ziemens, D, Untiet, V & Fahlke, C 2018, 'Molecular and cellular physiology of sodium-dependent glutamate transporters', Brain Research Bulletin, vol. 136, pp. 3-16. https://doi.org/10.1016/j.brainresbull.2016.12.013

APA

Rose, C. R., Ziemens, D., Untiet, V., & Fahlke, C. (2018). Molecular and cellular physiology of sodium-dependent glutamate transporters. Brain Research Bulletin, 136, 3-16. https://doi.org/10.1016/j.brainresbull.2016.12.013

Vancouver

Rose CR, Ziemens D, Untiet V, Fahlke C. Molecular and cellular physiology of sodium-dependent glutamate transporters. Brain Research Bulletin. 2018;136:3-16. https://doi.org/10.1016/j.brainresbull.2016.12.013

Author

Rose, Christine R ; Ziemens, Daniel ; Untiet, Verena ; Fahlke, Christoph. / Molecular and cellular physiology of sodium-dependent glutamate transporters. In: Brain Research Bulletin. 2018 ; Vol. 136. pp. 3-16.

Bibtex

@article{bcd179dbf8274e199de121a7ed5a2252,

title = "Molecular and cellular physiology of sodium-dependent glutamate transporters",

abstract = "Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma membrane transporters. While both neurons and glial cells express these excitatory amino acid transporters (EAATs), the majority of glutamate uptake is accomplished by astrocytes, which convert synaptically-released glutamate to glutamine or feed it into their own metabolism. Glutamate uptake by astrocytes not only shapes synaptic transmission by regulating the availability of glutamate to postsynaptic neuronal receptors, but also protects neurons from hyper-excitability and subsequent excitotoxic damage. In the present review, we provide an overview of the molecular and cellular characteristics of sodium-dependent glutamate transporters and their associated anion permeation pathways, with a focus on astrocytic glutamate transport. We summarize their functional properties and roles within tripartite synapses under physiological and pathophysiological conditions, exemplifying the intricate interactions and interrelationships between neurons and glial cells in the brain.",

keywords = "Animals, Astrocytes/metabolism, Glutamate Plasma Membrane Transport Proteins/chemistry, Glutamic Acid/metabolism, Humans, Neurons/metabolism",

author = "Rose, {Christine R} and Daniel Ziemens and Verena Untiet and Christoph Fahlke",

year = "2018",

doi = "10.1016/j.brainresbull.2016.12.013",

language = "English",

volume = "136",

pages = "3--16",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Molecular and cellular physiology of sodium-dependent glutamate transporters

AU - Rose, Christine R

AU - Ziemens, Daniel

AU - Untiet, Verena

AU - Fahlke, Christoph

PY - 2018

Y1 - 2018

N2 - Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma membrane transporters. While both neurons and glial cells express these excitatory amino acid transporters (EAATs), the majority of glutamate uptake is accomplished by astrocytes, which convert synaptically-released glutamate to glutamine or feed it into their own metabolism. Glutamate uptake by astrocytes not only shapes synaptic transmission by regulating the availability of glutamate to postsynaptic neuronal receptors, but also protects neurons from hyper-excitability and subsequent excitotoxic damage. In the present review, we provide an overview of the molecular and cellular characteristics of sodium-dependent glutamate transporters and their associated anion permeation pathways, with a focus on astrocytic glutamate transport. We summarize their functional properties and roles within tripartite synapses under physiological and pathophysiological conditions, exemplifying the intricate interactions and interrelationships between neurons and glial cells in the brain.

AB - Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma membrane transporters. While both neurons and glial cells express these excitatory amino acid transporters (EAATs), the majority of glutamate uptake is accomplished by astrocytes, which convert synaptically-released glutamate to glutamine or feed it into their own metabolism. Glutamate uptake by astrocytes not only shapes synaptic transmission by regulating the availability of glutamate to postsynaptic neuronal receptors, but also protects neurons from hyper-excitability and subsequent excitotoxic damage. In the present review, we provide an overview of the molecular and cellular characteristics of sodium-dependent glutamate transporters and their associated anion permeation pathways, with a focus on astrocytic glutamate transport. We summarize their functional properties and roles within tripartite synapses under physiological and pathophysiological conditions, exemplifying the intricate interactions and interrelationships between neurons and glial cells in the brain.

KW - Animals

KW - Astrocytes/metabolism

KW - Glutamate Plasma Membrane Transport Proteins/chemistry

KW - Glutamic Acid/metabolism

KW - Humans

KW - Neurons/metabolism

U2 - 10.1016/j.brainresbull.2016.12.013

DO - 10.1016/j.brainresbull.2016.12.013

M3 - Review

C2 - 28040508

VL - 136

SP - 3

EP - 16

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

ER -

ID: 209898677

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