Modeling oscillatory control in NF-¿B, p53 and Wnt signaling
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Modeling oscillatory control in NF-¿B, p53 and Wnt signaling. / Mengel, Benedicte; Hunziker, Alexander; Pedersen, Lykke; Trusina, Ala; Jensen, Mogens H; Krishna, Sandeep.
In: Current Opinion in Genetics & Development, Vol. 20, No. 6, 01.12.2010, p. 656-64.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modeling oscillatory control in NF-¿B, p53 and Wnt signaling
AU - Mengel, Benedicte
AU - Hunziker, Alexander
AU - Pedersen, Lykke
AU - Trusina, Ala
AU - Jensen, Mogens H
AU - Krishna, Sandeep
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Oscillations are commonly observed in cellular behavior and span a wide range of timescales, from seconds in calcium signaling to 24 hours in circadian rhythms. In between lie oscillations with time periods of 1-5 hours seen in NF-¿B, p53 and Wnt signaling, which play key roles in the immune system, cell growth/death and embryo development, respectively. In the first part of this article, we provide a brief overview of simple deterministic models of oscillations. In particular, we explain the mechanism of saturated degradation that has been used to model oscillations in the NF-¿B, p53 and Wnt systems. The second part deals with the potential physiological role of oscillations. We use the simple models described earlier to explore whether oscillatory signals can encode more information than steady-state signals. We then discuss a few simple genetic circuits that could decode information stored in the average, amplitude or frequency of oscillations. The presence of frequency-detector circuit downstream of NF-¿B or p53 would be a strong clue that oscillations are important for the physiological response of these signaling systems.
AB - Oscillations are commonly observed in cellular behavior and span a wide range of timescales, from seconds in calcium signaling to 24 hours in circadian rhythms. In between lie oscillations with time periods of 1-5 hours seen in NF-¿B, p53 and Wnt signaling, which play key roles in the immune system, cell growth/death and embryo development, respectively. In the first part of this article, we provide a brief overview of simple deterministic models of oscillations. In particular, we explain the mechanism of saturated degradation that has been used to model oscillations in the NF-¿B, p53 and Wnt systems. The second part deals with the potential physiological role of oscillations. We use the simple models described earlier to explore whether oscillatory signals can encode more information than steady-state signals. We then discuss a few simple genetic circuits that could decode information stored in the average, amplitude or frequency of oscillations. The presence of frequency-detector circuit downstream of NF-¿B or p53 would be a strong clue that oscillations are important for the physiological response of these signaling systems.
KW - Animals
KW - Circadian Rhythm
KW - Humans
KW - Models, Biological
KW - NF-kappa B
KW - Signal Transduction
KW - Tumor Suppressor Protein p53
KW - Wnt Proteins
U2 - 10.1016/j.gde.2010.08.008
DO - 10.1016/j.gde.2010.08.008
M3 - Journal article
C2 - 20934871
VL - 20
SP - 656
EP - 664
JO - Current Opinion in Genetics & Development
JF - Current Opinion in Genetics & Development
SN - 0959-437X
IS - 6
ER -
ID: 32671818