In this review, we present the status of mindfulness in the treatment of sexual difficulties in men and women. The prevalence of sexual difficulties is high among both men and women. Sexual difficulties are often associated with somatic and mental disorders, and therefore effective treatments are needed. Growing evidence shows, that standardised mindfulness programmes are effective in the treatment of stress, anxiety, depression and chronic pain. Evidence for mindfulness therapy in sexology is sparse, but results so far suggest, that mindfulness can be effective in sex therapy.