Methods for assessing intrahepatic fat content and steatosis
Research output: Contribution to journal › Review › Research › peer-review
Standard
Methods for assessing intrahepatic fat content and steatosis. / Fabbrini, Elisa; Conte, Caterina; Magkos, Faidon.
In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 12, No. 5, 09.2009, p. 474-481.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Methods for assessing intrahepatic fat content and steatosis
AU - Fabbrini, Elisa
AU - Conte, Caterina
AU - Magkos, Faidon
N1 - (Ekstern)
PY - 2009/9
Y1 - 2009/9
N2 - Purpose of review: Intrahepatic fat content is increasingly being recognized as an integral part of metabolic dysfunction. This article reviews available methods for the assessment of hepatic steatosis.Recent findings: Apart from liver biopsy, there are several noninvasive radiologic modalities for evaluating nonalcoholic fatty liver disease. Ultrasonography, computed tomography, and traditional MRI remain largely qualitative methods for detecting mild to severe degrees of steatosis rather than quantitative methods for measuring liver fat content, even though novel attempts to collect objective quantitative information have recently been developed. Still, their sensitivity at mild degrees of steatosis is poor. Undoubtedly, most methodological advances have occurred in the field of MRI and magnetic resonance spectroscopy, which currently enable the accurate quantification of intrahepatic fat even at normal or near normal levels. Xenon computed tomography was also recently shown to offer another objective tool for the quantitative assessment of steatosis, although more validation studies are required.Summary: Several modalities can be used for measuring intrahepatic fat and assessing steatosis; the choice will ultimately depend on the intended use and available resources.
AB - Purpose of review: Intrahepatic fat content is increasingly being recognized as an integral part of metabolic dysfunction. This article reviews available methods for the assessment of hepatic steatosis.Recent findings: Apart from liver biopsy, there are several noninvasive radiologic modalities for evaluating nonalcoholic fatty liver disease. Ultrasonography, computed tomography, and traditional MRI remain largely qualitative methods for detecting mild to severe degrees of steatosis rather than quantitative methods for measuring liver fat content, even though novel attempts to collect objective quantitative information have recently been developed. Still, their sensitivity at mild degrees of steatosis is poor. Undoubtedly, most methodological advances have occurred in the field of MRI and magnetic resonance spectroscopy, which currently enable the accurate quantification of intrahepatic fat even at normal or near normal levels. Xenon computed tomography was also recently shown to offer another objective tool for the quantitative assessment of steatosis, although more validation studies are required.Summary: Several modalities can be used for measuring intrahepatic fat and assessing steatosis; the choice will ultimately depend on the intended use and available resources.
KW - Biopsy
KW - Body Fat Distribution
KW - Fatty Liver/diagnosis
KW - Humans
KW - Liver/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Magnetic Resonance Spectroscopy
KW - Tomography, X-Ray Computed
KW - Triglycerides/metabolism
KW - Ultrasonography
U2 - 10.1097/MCO.0b013e32832eb587
DO - 10.1097/MCO.0b013e32832eb587
M3 - Review
C2 - 19550313
VL - 12
SP - 474
EP - 481
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
SN - 1363-1950
IS - 5
ER -
ID: 290671667