Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
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Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells. / Kappe, Camilla; Patrone, Cesare; Holst, Jens Juul; Zhang, Qimin; Sjöholm, Ake.
In: Journal of Gastroenterology, Vol. 48, No. 3, 03.2013, p. 322-32.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
AU - Kappe, Camilla
AU - Patrone, Cesare
AU - Holst, Jens Juul
AU - Zhang, Qimin
AU - Sjöholm, Ake
PY - 2013/3
Y1 - 2013/3
N2 - Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
AB - Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
U2 - 10.1007/s00535-012-0637-5
DO - 10.1007/s00535-012-0637-5
M3 - Journal article
C2 - 22850868
VL - 48
SP - 322
EP - 332
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 3
ER -
ID: 45840439