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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. / Zeggini, Eleftheria; Scott, Laura J; Saxena, Richa; Voight, Benjamin F; Marchini, Jonathan L; Hu, Tianle; de Bakker, Paul I W; Abecasis, Gonçalo R; Almgren, Peter; Andersen, Gitte; Ardlie, Kristin; Boström, Kristina Bengtsson; Bergman, Richard N; Bonnycastle, Lori L; Borch-Johnsen, Knut; Burtt, Noël P; Chen, Hong; Chines, Peter S; Daly, Mark J; Deodhar, Parimal; Ding, Chia-Jen; Doney, Alex S F; Duren, William L; Elliott, Katherine S; Erdos, Michael R; Frayling, Timothy M; Freathy, Rachel M; Gianniny, Lauren; Grallert, Harald; Grarup, Niels; Groves, Christopher J; Guiducci, Candace; Hansen, Torben; Herder, Christian; Hitman, Graham A; Hughes, Thomas E; Isomaa, Bo; Jackson, Anne U; Jørgensen, Torben; Kong, Augustine; Kubalanza, Kari; Kuruvilla, Finny G; Kuusisto, Johanna; Langenberg, Claudia; Lango, Hana; Lauritzen, Torsten; Li, Yun; Lindgren, Cecilia M; Lyssenko, Valeriya; Wellcome Trust Case Control Consortium ; Pedersen, Oluf.
In:
Nature Genetics, Vol. 40, No. 5, 2008, p. 638-45.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Zeggini, E, Scott, LJ, Saxena, R, Voight, BF, Marchini, JL, Hu, T, de Bakker, PIW, Abecasis, GR, Almgren, P, Andersen, G, Ardlie, K, Boström, KB, Bergman, RN, Bonnycastle, LL, Borch-Johnsen, K, Burtt, NP, Chen, H, Chines, PS, Daly, MJ, Deodhar, P, Ding, C-J, Doney, ASF, Duren, WL, Elliott, KS, Erdos, MR, Frayling, TM, Freathy, RM, Gianniny, L, Grallert, H, Grarup, N, Groves, CJ, Guiducci, C
, Hansen, T, Herder, C, Hitman, GA, Hughes, TE, Isomaa, B, Jackson, AU, Jørgensen, T, Kong, A, Kubalanza, K, Kuruvilla, FG, Kuusisto, J, Langenberg, C, Lango, H, Lauritzen, T, Li, Y, Lindgren, CM, Lyssenko, V, Wellcome Trust Case Control Consortium
& Pedersen, O 2008, '
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes',
Nature Genetics, vol. 40, no. 5, pp. 638-45.
https://doi.org/10.1038/ng.120
APA
Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I. W., Abecasis, G. R., Almgren, P., Andersen, G., Ardlie, K., Boström, K. B., Bergman, R. N., Bonnycastle, L. L., Borch-Johnsen, K., Burtt, N. P., Chen, H., Chines, P. S., Daly, M. J.
, ... Pedersen, O. (2008).
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nature Genetics,
40(5), 638-45.
https://doi.org/10.1038/ng.120
Vancouver
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T et al.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nature Genetics. 2008;40(5):638-45.
https://doi.org/10.1038/ng.120
Author
Zeggini, Eleftheria ; Scott, Laura J ; Saxena, Richa ; Voight, Benjamin F ; Marchini, Jonathan L ; Hu, Tianle ; de Bakker, Paul I W ; Abecasis, Gonçalo R ; Almgren, Peter ; Andersen, Gitte ; Ardlie, Kristin ; Boström, Kristina Bengtsson ; Bergman, Richard N ; Bonnycastle, Lori L ; Borch-Johnsen, Knut ; Burtt, Noël P ; Chen, Hong ; Chines, Peter S ; Daly, Mark J ; Deodhar, Parimal ; Ding, Chia-Jen ; Doney, Alex S F ; Duren, William L ; Elliott, Katherine S ; Erdos, Michael R ; Frayling, Timothy M ; Freathy, Rachel M ; Gianniny, Lauren ; Grallert, Harald ; Grarup, Niels ; Groves, Christopher J ; Guiducci, Candace ; Hansen, Torben ; Herder, Christian ; Hitman, Graham A ; Hughes, Thomas E ; Isomaa, Bo ; Jackson, Anne U ; Jørgensen, Torben ; Kong, Augustine ; Kubalanza, Kari ; Kuruvilla, Finny G ; Kuusisto, Johanna ; Langenberg, Claudia ; Lango, Hana ; Lauritzen, Torsten ; Li, Yun ; Lindgren, Cecilia M ; Lyssenko, Valeriya ; Wellcome Trust Case Control Consortium ; Pedersen, Oluf. / Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. In: Nature Genetics. 2008 ; Vol. 40, No. 5. pp. 638-45.
Bibtex
@article{42d35a80ee1e11ddbf70000ea68e967b,
title = "Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes",
abstract = "Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.",
author = "Eleftheria Zeggini and Scott, {Laura J} and Richa Saxena and Voight, {Benjamin F} and Marchini, {Jonathan L} and Tianle Hu and {de Bakker}, {Paul I W} and Abecasis, {Gon{\c c}alo R} and Peter Almgren and Gitte Andersen and Kristin Ardlie and Bostr{\"o}m, {Kristina Bengtsson} and Bergman, {Richard N} and Bonnycastle, {Lori L} and Knut Borch-Johnsen and Burtt, {No{\"e}l P} and Hong Chen and Chines, {Peter S} and Daly, {Mark J} and Parimal Deodhar and Chia-Jen Ding and Doney, {Alex S F} and Duren, {William L} and Elliott, {Katherine S} and Erdos, {Michael R} and Frayling, {Timothy M} and Freathy, {Rachel M} and Lauren Gianniny and Harald Grallert and Niels Grarup and Groves, {Christopher J} and Candace Guiducci and Torben Hansen and Christian Herder and Hitman, {Graham A} and Hughes, {Thomas E} and Bo Isomaa and Jackson, {Anne U} and Torben J{\o}rgensen and Augustine Kong and Kari Kubalanza and Kuruvilla, {Finny G} and Johanna Kuusisto and Claudia Langenberg and Hana Lango and Torsten Lauritzen and Yun Li and Lindgren, {Cecilia M} and Valeriya Lyssenko and {Wellcome Trust Case Control Consortium} and Oluf Pedersen",
note = "Keywords: Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genome, Human; Humans; Polymorphism, Single Nucleotide",
year = "2008",
doi = "10.1038/ng.120",
language = "English",
volume = "40",
pages = "638--45",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "5",
}
RIS
TY - JOUR
T1 - Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
AU - Zeggini, Eleftheria
AU - Scott, Laura J
AU - Saxena, Richa
AU - Voight, Benjamin F
AU - Marchini, Jonathan L
AU - Hu, Tianle
AU - de Bakker, Paul I W
AU - Abecasis, Gonçalo R
AU - Almgren, Peter
AU - Andersen, Gitte
AU - Ardlie, Kristin
AU - Boström, Kristina Bengtsson
AU - Bergman, Richard N
AU - Bonnycastle, Lori L
AU - Borch-Johnsen, Knut
AU - Burtt, Noël P
AU - Chen, Hong
AU - Chines, Peter S
AU - Daly, Mark J
AU - Deodhar, Parimal
AU - Ding, Chia-Jen
AU - Doney, Alex S F
AU - Duren, William L
AU - Elliott, Katherine S
AU - Erdos, Michael R
AU - Frayling, Timothy M
AU - Freathy, Rachel M
AU - Gianniny, Lauren
AU - Grallert, Harald
AU - Grarup, Niels
AU - Groves, Christopher J
AU - Guiducci, Candace
AU - Hansen, Torben
AU - Herder, Christian
AU - Hitman, Graham A
AU - Hughes, Thomas E
AU - Isomaa, Bo
AU - Jackson, Anne U
AU - Jørgensen, Torben
AU - Kong, Augustine
AU - Kubalanza, Kari
AU - Kuruvilla, Finny G
AU - Kuusisto, Johanna
AU - Langenberg, Claudia
AU - Lango, Hana
AU - Lauritzen, Torsten
AU - Li, Yun
AU - Lindgren, Cecilia M
AU - Lyssenko, Valeriya
AU - Wellcome Trust Case Control Consortium
AU - Pedersen, Oluf
N1 - Keywords: Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genome, Human; Humans; Polymorphism, Single Nucleotide
PY - 2008
Y1 - 2008
N2 - Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
AB - Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
U2 - 10.1038/ng.120
DO - 10.1038/ng.120
M3 - Journal article
C2 - 18372903
VL - 40
SP - 638
EP - 645
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 5
ER -