Mechanisms behind functional avidity maturation in T cells
Research output: Contribution to journal › Journal article › Research › peer-review
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.
Original language | English |
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Article number | 163453 |
Journal | Clinical & Developmental Immunology |
Volume | 2012 |
Number of pages | 8 |
ISSN | 1740-2522 |
DOIs | |
Publication status | Published - Jan 2012 |
- Animals, Cell Differentiation, Cellular Microenvironment, Cytokines, Humans, Immunologic Memory, Lymphocyte Activation, Receptor Cross-Talk, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes
Research areas
ID: 46485143