Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity. / Crean, A. J.; Afrin, S.; Niranjan, H.; Pulpitel, T. J.; Ahmad, G.; Senior, A. M.; Freire, T.; Mackay, F.; Nobrega, M. A.; Barrès, R.; Simpson, S. J.; Pini, T.

In: Nature Communications, Vol. 14, No. 1, 2566, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Crean, AJ, Afrin, S, Niranjan, H, Pulpitel, TJ, Ahmad, G, Senior, AM, Freire, T, Mackay, F, Nobrega, MA, Barrès, R, Simpson, SJ & Pini, T 2023, 'Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity', Nature Communications, vol. 14, no. 1, 2566. https://doi.org/10.1038/s41467-023-38314-x

APA

Crean, A. J., Afrin, S., Niranjan, H., Pulpitel, T. J., Ahmad, G., Senior, A. M., Freire, T., Mackay, F., Nobrega, M. A., Barrès, R., Simpson, S. J., & Pini, T. (2023). Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity. Nature Communications, 14(1), [2566]. https://doi.org/10.1038/s41467-023-38314-x

Vancouver

Crean AJ, Afrin S, Niranjan H, Pulpitel TJ, Ahmad G, Senior AM et al. Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity. Nature Communications. 2023;14(1). 2566. https://doi.org/10.1038/s41467-023-38314-x

Author

Crean, A. J. ; Afrin, S. ; Niranjan, H. ; Pulpitel, T. J. ; Ahmad, G. ; Senior, A. M. ; Freire, T. ; Mackay, F. ; Nobrega, M. A. ; Barrès, R. ; Simpson, S. J. ; Pini, T. / Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity. In: Nature Communications. 2023 ; Vol. 14, No. 1.

Bibtex

@article{183b110c8bbf41e9bed7ddf0433554bd,
title = "Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity",
abstract = "Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.",
author = "Crean, {A. J.} and S. Afrin and H. Niranjan and Pulpitel, {T. J.} and G. Ahmad and Senior, {A. M.} and T. Freire and F. Mackay and Nobrega, {M. A.} and R. Barr{\`e}s and Simpson, {S. J.} and T. Pini",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41467-023-38314-x",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity

AU - Crean, A. J.

AU - Afrin, S.

AU - Niranjan, H.

AU - Pulpitel, T. J.

AU - Ahmad, G.

AU - Senior, A. M.

AU - Freire, T.

AU - Mackay, F.

AU - Nobrega, M. A.

AU - Barrès, R.

AU - Simpson, S. J.

AU - Pini, T.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.

AB - Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.

U2 - 10.1038/s41467-023-38314-x

DO - 10.1038/s41467-023-38314-x

M3 - Journal article

C2 - 37142562

AN - SCOPUS:85158044998

VL - 14

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 2566

ER -

ID: 347485438