Long working hours and cancer risk: a multi-cohort study
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Long working hours and cancer risk : a multi-cohort study. / Heikkila, Katriina; Nyberg, Solja T.; Madsen, Ida E. H.; de Vroome, Ernest; Alfredsson, Lars; Bjorner, Jakob J.; Borritz, Marianne; Burr, Hermann; Erbel, Raimund; Ferrie, Jane E.; Fransson, Eleonor I.; Geuskens, Goedele A.; Hooftman, Wendela E.; Houtman, Irene L.; Joeckel, Karl-Heinz; Knutsson, Anders; Koskenvuo, Markku; Lunau, Thorsten; Nielsen, Martin L.; Nordin, Maria; Oksanen, Tuula; Pejtersen, Jan H.; Pentti, Jaana; Shipley, Martin J.; Steptoe, Andrew; Suominen, Sakari B.; Theorell, Toeres; Vahtera, Jussi; Westerholm, Peter J. M.; Westerlund, Hugo; Dragano, Nico; Rugulies, Reiner; Kawachi, Ichiro; Batty, G. David; Singh-Manoux, Archana; Virtanen, Marianna; Kivimaki, Mika.
In: B J C, Vol. 114, 2016, p. 813-818.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long working hours and cancer risk
T2 - a multi-cohort study
AU - Heikkila, Katriina
AU - Nyberg, Solja T.
AU - Madsen, Ida E. H.
AU - de Vroome, Ernest
AU - Alfredsson, Lars
AU - Bjorner, Jakob J.
AU - Borritz, Marianne
AU - Burr, Hermann
AU - Erbel, Raimund
AU - Ferrie, Jane E.
AU - Fransson, Eleonor I.
AU - Geuskens, Goedele A.
AU - Hooftman, Wendela E.
AU - Houtman, Irene L.
AU - Joeckel, Karl-Heinz
AU - Knutsson, Anders
AU - Koskenvuo, Markku
AU - Lunau, Thorsten
AU - Nielsen, Martin L.
AU - Nordin, Maria
AU - Oksanen, Tuula
AU - Pejtersen, Jan H.
AU - Pentti, Jaana
AU - Shipley, Martin J.
AU - Steptoe, Andrew
AU - Suominen, Sakari B.
AU - Theorell, Toeres
AU - Vahtera, Jussi
AU - Westerholm, Peter J. M.
AU - Westerlund, Hugo
AU - Dragano, Nico
AU - Rugulies, Reiner
AU - Kawachi, Ichiro
AU - Batty, G. David
AU - Singh-Manoux, Archana
AU - Virtanen, Marianna
AU - Kivimaki, Mika
PY - 2016
Y1 - 2016
N2 - Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported.Results: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working greater than or equal to55 h per week was associated with 1.60-fold (95% confidence interval 1.12–2.29) increase in female breast cancer risk independently of age, socioeconomic position, shift- and night-time work and lifestyle factors, but this observation may have been influenced by residual confounding from parity.Conclusions: Our findings suggest that working long hours is unrelated to the overall cancer risk or the risk of lung, colorectal or prostate cancers. The observed association with breast cancer would warrant further research.
AB - Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported.Results: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working greater than or equal to55 h per week was associated with 1.60-fold (95% confidence interval 1.12–2.29) increase in female breast cancer risk independently of age, socioeconomic position, shift- and night-time work and lifestyle factors, but this observation may have been influenced by residual confounding from parity.Conclusions: Our findings suggest that working long hours is unrelated to the overall cancer risk or the risk of lung, colorectal or prostate cancers. The observed association with breast cancer would warrant further research.
KW - Breast cancer
KW - colorectal cancer
KW - lung cancer
KW - prostate cancer
KW - working hours
U2 - 10.1038/bjc.2016.9
DO - 10.1038/bjc.2016.9
M3 - Journal article
C2 - 26889978
VL - 114
SP - 813
EP - 818
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
ER -
ID: 162604233