Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion
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Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion. / Ziegler, Hanne L; Staalsø, Trine; Jaroszewski, Jerzy W.
In: Planta Medica, Vol. 72, No. 7, 2006, p. 640-2.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion
AU - Ziegler, Hanne L
AU - Staalsø, Trine
AU - Jaroszewski, Jerzy W
N1 - Keywords: Animals; Antimalarials; Erythrocyte Membrane; Humans; Plasmodium falciparum; Triterpenes
PY - 2006
Y1 - 2006
N2 - Lupeol and betulinic acid inhibit the proliferation of Plasmodium falciparum parasites by inhibition of the invasion of merozoites into erythrocytes. This conclusion is based on experiments employing parasite cultures synchronized by magnetic cell sorting (MACS). Identical inhibitory effects were observed upon incubation of synchronous parasite cultures in the presence of the triterpenoids, and when the parasite cultures were grown in a triterpenoid-free medium with erythrocytes preloaded with the triterpenoids.
AB - Lupeol and betulinic acid inhibit the proliferation of Plasmodium falciparum parasites by inhibition of the invasion of merozoites into erythrocytes. This conclusion is based on experiments employing parasite cultures synchronized by magnetic cell sorting (MACS). Identical inhibitory effects were observed upon incubation of synchronous parasite cultures in the presence of the triterpenoids, and when the parasite cultures were grown in a triterpenoid-free medium with erythrocytes preloaded with the triterpenoids.
U2 - 10.1055/s-2006-931575
DO - 10.1055/s-2006-931575
M3 - Journal article
C2 - 16732511
VL - 72
SP - 640
EP - 642
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 7
ER -
ID: 17274503