Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet
Research output: Contribution to journal › Journal article › Research › peer-review
Objective: Short-term energy deprivation reduces leptin concentrations and alters the levels of circulating hormones of the hypothalamic-pituitary-peripheral axis in lean subjects. Whether the reduction in leptin concentration during long-term weight loss in obese individuals is linked to the same neuroendocrine changes seen in lean, leptin-sensitive subjects remains to be fully clarified.
Methods: In this study, 24 overweight and obese adults (16 women and eight men; body mass index (BMI): 27.5-38.0 kg/m(2)) were prescribed a hypocaloric diet (-500 kcal/day) and were randomized to receive recombinant methionyl leptin (n=18, metreleptin, 10 mg/day self-injected s.c.) or placebo (n=6, same volume and time as metreleptin) for 6 months.
Results: Metreleptin administration did not affect weight loss beyond that induced by hypocaloric diet alone (P for interaction=0.341) but increased the serum concentrations of total leptin by six- to eight-fold (P<0.001) and led to the generation of anti-leptin antibodies. Despite free leptin concentration (P for interaction=0.041) increasing from 9±1 ng/ml at baseline to 43±15 and 36±12 ng/ml at 3 and 6 months, respectively, changes in circulating hormones of the thyroid and IGF axes at 3 and 6 months were not significantly different in the placebo- and metreleptin-treated groups.
Conclusions: Leptin does not likely mediate changes in neuroendocrine function in response to weight loss induced by a mild hypocaloric diet in overweight and obese subjects.
Original language | English |
---|---|
Journal | European Journal of Endocrinology |
Volume | 165 |
Issue number | 2 |
Pages (from-to) | 249-254 |
Number of pages | 6 |
ISSN | 0804-4643 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |
- Adult, Aged, Caloric Restriction, Diet, Reducing, Drug Administration Schedule, Female, Humans, Leptin/administration & dosage, Male, Middle Aged, Obesity/blood, Osmolar Concentration, Overweight/blood, Signal Transduction/drug effects, Somatomedins/analysis, Thyroid Gland/drug effects, Thyroid Hormones/blood, Time Factors, Weight Loss/drug effects, Young Adult
Research areas
ID: 290039709